Two hematopoietic-specific adapters, src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) and linker for activation of T cells (LAT), are critical for T cell development and T cell receptor (TCR) signaling. Several studies have suggested that SLP-76 and LAT function coordinately to promote downstream signaling. In support of this hypothesis, we find that a fraction of SLP...

T cell receptor (TCR) signaling involves CD4/CD8-p56lck recruitment of ZAP-70 to the TCR receptor, ZAP-70 phosphorylation of LAT that is followed by LAT recruitment of the GADS-SLP-76 complex. Back regulation of ZAP-70 by SLP-76 has not been documented. In this paper, we show that anti-CD3 induced ZAP-70 cluster formation is significantly reduced in the absence of SLP-76 (i.e., J14 cells) and i...

OBJECTIVE To compare the ability of scanning laser polarimetry (SLP) to discriminate between healthy and glaucomatous eyes with manufacturer-assumed fixed and subject-specific variable corneal polarization magnitude (CPM) and corneal polarization axis (CPA) values. METHODS An SLP was modified to enable the measurement of CPM and CPA values so that compensation for corneal birefringence could ...

PURPOSE To undertake a community (nonclinical) study to describe the speech of preschool children who had been identified by parents/teachers as having difficulties "talking and making speech sounds" and compare the speech characteristics of those who had and had not accessed the services of a speech-language pathologist (SLP). METHOD Stage 1: Parent/teacher concern regarding the speech skill...

This study presented an innovative Bayesian Network (BN) modelling andsimulation for supplier selection problem of actual electronic parts manufacturing firm Pakistan.The list qualitative and quantitative factors which affect this decision wasextracted from a variety studies in literature. The was modelled solved respectiveBN software platform using the standard recommended procedure. Results s...

We introduce classes of utility functions and production sets, called Leontief-free, which are applicable when goods are substitutes and utilities/production are sub-additive (to model intergood satiation). When goods are complements, the well studied Leontief utility functions do an adequate job; however, to the best of our knowledge, a similar concept for the case of goods that are substitute...

This paper extends previous works that view transit systems as minimizing their after-subsidy costs. The paper uses the expense preference behavior model in economics and derives ®rst-order conditions for the manager. From the ®rst-order conditions, the paper formally shows that the decomposition of relative price ineciency between management behavior and subsidies found in the work of Sakano ...

CONTRIBUTING AUTHORS: Robin Alvares, PhD, CCCSLP; Marnee Brick, MSc, S-LP; Kelly J. Brown, MA; Michael F. Campbell, MS, MBA, CCC-SLP; Charles H. Carlin, PhD, CCC-SLP; Emily L. Carlin, MA, CCC-SLP; Gabriella Constantinescu, PhD, BSpPath (Hons); Sena Crutchley, MS, CCC-SLP; Dimity Dornan, AM, Associate Professor UQ, HonDUniv USQ, BSpThy, FSPAA, CpSp, LSLS Cert AVT; Anne M. Fleming, MA; Rodney Gab...

The neural circuitry and biomechanics of kicking in locusts have been studied to understand their roles in the control of both kicking and jumping. It has been hypothesized that the same neural circuit and biomechanics governed both behaviors but this hypothesis was not testable with current technology. We built a neuromechanical model to test this and to gain a better understanding of the role...

BACKGROUND AND OBJECTIVES Presently, cutaneous vascular lesions are treated using a single cryogen spurt and single laser pulse (SCS-SLP), which do not necessarily produce complete lesion removal in the majority of patients. In this study, the feasibility of applying multiple cryogen spurts intermittently with multiple two-wavelength laser pulses (MCS-MTWLP) was studied using numerical and anim...