This study is pertaining to the production of penicillin G acylase (PGA) by Bacillus subtilis 8105MU331 in which PGA gene, under the control of thermal-induced promoter, was integrated. The key process parameters including induced-temperature, induced-time, and culture temperature were optimized in flask culture. A three-stage cultivation process was developed for PGA production with the expres...

in this paper, a hybrid method for limited resource allocation and leveling in complex multi-stage, multi-product and multi-period production planning problems with aim of lot-size determination and total cost minimization has been proposed. this problem consists of multiple products with sequential production processes that are produced in different periods to meet the customers demand. by det...

The current study investigates performance in two-stage production systems through the measurement of capacity utilization (CU). In short-run, the degree of capacity utilization depends on the ability of decision making units to utilize fixed production factors. To develop this indicator in two-stage production processes, a modified SBM network DEA model is proposed. A numerical example is also...

A multi-stage Kanban based production system (MKPS) with variable production rates is considered. This paper is to study and analyse the process of designing an effective flexible Kanban pull system and to design and develop a method for MKPS with varying production rate at different work-stage. Raw materials are replenished at the first work-stage and they are processed through MKPS to generat...

Abstract Participatory scenario visioning aims to expose, integrate, and reconcile perspectives expectations about a sustainable, resilient future from variety of actors stakeholders. This chapter considers the settings in which transdisciplinary participatory takes place, highlighting lessons learned Urban Resilience Extremes Sustainability Research Network (UREx SRN). It reflects on benefits ...

Prevalences in terms of the number of eggs contaminated (internally and externally) with Salmonella Enteritidis per million are presented based on a 2 stage Bayesian model. The first stage estimates the average flock prevalence over laying period in the production system and the second stage estimates the proportion of contaminated eggs for an infected flock. These are combined to give the expe...

An important aim of automation is to increase productivity and to decrease costs. In the past automation was mainly focused on steering and controlling motions and operation sequences. In many cases the sensory capabilities of automated production systems are underdeveloped and quality inspection is still carried out manually and visually. By using automated visual inspection systems and digita...

Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV) for...