Background: Reported concentrations of amyloid(1– 42) (A 42) and tau in cerebrospinal fluid (CSF) differ among reports. We investigated the effects of storage temperature, repeated freeze/thaw cycles, and centrifugation on the concentrations of A 42 and tau in CSF. Methods: Stability of samples stored at 80 °C was determined by use of an accelerated stability testing protocol according to the A...

We conducted a clinical trial of oral valganciclovir, a drug with in vitro activity against Kaposi sarcoma (KS)-associated herpesvirus (KSHV), in classic KS. Five human immunodeficiency virus-seronegative participants received valganciclovir for up to six 4-week cycles at doses used for cytomegalovirus infection. None of the study subjects showed an objective response; KS progressed in 4 subjec...

We compare different preference restrictions that ensure the existence of a stable roommate matching. Some of these restrictions are generalized to allow for indifferences as well as incomplete preference lists, in the sense that an agent may prefer remaining single to matching with some agents. We also introduce a new type of cycles and in greater detail investigate the domain of preferences t...

We show that certain geometrically defined higher codimension cycles are extremal in the effective cone of the moduli spaceMg,n of stable genus g curves with n ordered marked points. In particular, we prove that codimension two boundary strata are extremal and exhibit extremal boundary strata of higher codimension. We also show that the locus of hyperelliptic curves with a marked Weierstrass po...

We present an evolutionary model that marks an encounter of two seemingly unrelated disciplines: population dynamics and number theory. Assuming mutations and selection of predators and prey, we show that prey cycles with non-prime lengths are unstable, while cycles with prime lenghts are stable. Allowing arbitrarily long cycles, this model is a number-theoretical tool for the calculation of la...

The influence of small noise on the dynamics of heteroclinic networks is studied, with a particular focus on noise-induced switching between cycles in the network. Three different types of switching are found, depending on the details of the underlying deterministic dynamics: random switching between the heteroclinic cycles determined by the linear dynamics near one of the saddle points, noise ...

We consider coalition formation among players in an n-player finite strategic game over infinite horizon. At each time a randomly formed coalition makes a joint deviation from a current action profile such that at new action profile all players from the coalition are strictly benefited. Such deviations define a coalitional better-response (CBR) dynamics that is in general stochastic. The CBR dy...

The problem of limit cycles for Kolmogorov model is interesting and significant both in theory and applications. Our work is concerned with limit cycles bifurcations problem for a class of quartic Kolmogorov model with two positive singular points (i.e. (1, 2) and (2, 1)). The investigated model is symmetrical with regard to y = x. We show that each one of points (1, 2) and (2, 1) can bifurcate...

We define the notion of mirror of a Calabi-Yau manifold with a stable bundle in the context of type II strings in terms of supersymmetric cycles on the mirror. This allows us to relate the variation of Hodge structure for cohomologies arising from the bundle to the counting of holomorphic maps of Riemann surfaces with boundary on the mirror side. Moreover it opens up the possibility of studying...