For the cost and cost-effectiveness outcomes, the authors searched the databases of MEDLINE, Health Planning and Administration, the Office of Health Economics and the NHS CRD's NHS EED. The search terms used are listed in an appendix to the review. The authors search strategy was developed using standard systematic review techniques and had five components: sources of evidence (the databases s...

Case study: A 62-year-old male smoker with type 2 diabetes mellitus and hypertension presents with a 4-month history of exertional chest pain. Physical examination shows a blood pressure of 152/90 mm Hg but is otherwise unremarkable. The ECG is normal, and laboratory tests show a fasting blood glucose value of 110 mg/dL, glycosylated hemoglobin 6.0%, creatinine 1.1 mg/dL, total cholesterol 160,...

Coronary artery disease is a chronic medical condition associated with high mortality and morbidity. Among individuals with coronary artery disease, more than 50% have chronic stable angina. Recent evidence supports initial treatment with medical therapy, followed by revascularization, if indicated, in patients with chronic stable angina. The successful management of patients with chronic stabl...

GeorGe Andrikopoulos1, John pArissis2, GerAsimos FilippAtos2, mAriA nikolAou3, konstAntinos pAntos4, VAsileios Voudris5, hArAlAmbos kArVounis6, dimitris Alexopoulos7, John GoudeVenos8; tAsk Force on the mAnAGement oF stAble AnGinA oF the hellenic cArdioVAsculAr reseArch society 1Henry Dunant Hospital, Athens, 2Attikon University Hospital, Athens, 3Hellenic Cardiovascular Research Society, 4Depa...

BACKGROUND Proinflammatory cytokines play a role in acute coronary events. However, the potential role of antiinflammatory cytokines in the modulation of the atherosclerotic process remains unknown. Interleukin (IL)-10, which is expressed in human atherosclerotic plaques, has potent deactivating properties in macrophages and T cells. The aim of this study was to assess whether serum concentrati...

British Journal of General Practice, June 2004 411 evaluated in US settings predominantly with self-selected well educated participants.9 It is being rolled out nationally before the local evaluation is completed, and despite the fact that initial results from the evaluation suggest poor uptake.10 More disappointing is that the Department of Health may find that they have bought a time-share wh...