Single Step Tableaux (SST) are the basis of a calculus for modal logics that combines different features of sequent and prefixed tableaux into a simple, modular, strongly analytic, and effective calculus for a wide range of modal logics. The paper presents a number of the computational results about SST (confluence, decidability, space complexity, modularity, etc.) and compares SST with other f...

Cushing’s disease is Cushing’s syndrome caused by an adrenocorticotropic hormone-secreting pituitary adenoma and, in the absence of adequate treatment, can be fatal. Cushing’s disease represents an unmet medical need, with no approved medical therapies. Pasireotide is a novel multi-receptor-targeted somatostatin analogue with high affinity for sst 1,2,3 and sst 5 . Compared with octreotide, pas...

Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory, and cognitive processes. Five somatostatin receptors have been described: sst(1), sst(2) (A and B), sst(3), sst(4), and sst(5), all belonging to the G-protein-coupled receptor family. During the recent years, numerous studies contributed to clarify the role of soma...

The Antarctic circumpolar wave (ACW) is a nominal 4-yr climate signal in the ocean–atmosphere system in the Southern Ocean, propagating eastward at an average speed of 6–8 cm s21, composed of two waves taking approximately 8 years to circle the globe. The ACW is characterized by a persistent phase relationship between warm (cool) sea surface temperature (SST) anomalies and poleward (equatorward...

UNLABELLED A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin receptor (sst)-positive tumors. Bicyclic somatostatin-based radiopeptides have not been studied yet. Hypothesizing that the introduction of conformational constraints may lead to receptor subtype selectivity or may help to delineate structural features determining pansomatostatin potency,...

[1] Restricted zones of recent dissolution and secondary aragonite infilling were identified in a coral core collected in 1986 from a living massive Porites colony from the central Great Barrier Reef, Australia. Secondary aragonite needles, 20 mm long, cover skeletal surfaces deposited from 1972 to late 1974 and increase bulk density by 10%. Dissolution is observed above this zone, whereas olde...

[1] The relationships among the boreal spring Southern Hemisphere Annular Mode (SAM), the Indian Ocean (IO) sea surface temperature (SST), and East Asian summer monsoon (EASM) are examined statistically in this paper. The variability of boreal spring SAM is closely related to the IO SST. When the SAM is in its strong positive phase in boreal spring, with low-pressure anomalies over the south po...

Article Summary) The Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI) with the capability of measuring sea surface temperature (SST) in the presence of clouds, has been providing an unprecedented view of tropical basin-scale SST variability. In this paper, an assessment of the accuracy of the SST derived from TMI over the Bay of Bengal using in situ data collected from moored b...

Central equatorial Paciic sea surface temperature (SST) anomaly is a critical predictor of basin-wide oceanographic and atmospheric eeects of the El Ni~ no-Southern Oscillation (ENSO) phenomenon. We employ two geochemical thermometers measured on coralline aragonite to reconstruct an independent proxy-based measure of central equatorial Paciic sea surface temperature anomaly. In addition, we as...

We examined the effects of somatostatin (SST) on neurons in the thalamic reticular nucleus (RT) using whole-cell patch-clamp techniques applied to visualized neurons in rat thalamic slices. SST, acting via sst(5) receptors and pertussis toxin-sensitive G-proteins, activated an inwardly rectifying K(+) (GIRK) current in 20 of 28 recorded cells to increase input conductance 15 +/- 3% above contro...