OBJECTIVE To compare the relative healthcare costs, from the perspective of the Spanish National Healthcare System (NHS), of initiating treatment with either pregabalin, or SSRI/SNRI, as add-on therapies, in patients with generalized anxiety disorder (GAD), who are resistant to benzodiazepine-based therapy (BR). METHODS BR out-patients with GAD (DSM-IV) who were included in a 6-month, prospec...

OBJECTIVE This is a prospective study of the effects of maternal use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy on newborn neurobehavioral integrity, including systematic measures of behavioral state, sleep organization, motor activity, heart rate variability (HRV), tremulousness, and startles. METHODS The sample included 17 SSRI-exposed and 17 nonexposed, full-birth-...

CONTEXT Polymorphisms in the serotonin transporter gene (5-HTT) may influence antidepressant response to selective serotonin reuptake inhibitors (SSRIs). The norepinephrine transporter (NET) is the analogous target for norepinephrine reuptake inhibitors (NRIs). OBJECTIVE To determine whether antidepressant responses to SSRIs or NRIs are associated with genetic polymorphisms of the correspondi...

Background Animal studies indicate a potential protective role of antidepressant medication (ADM) in models colitis but the effect their use humans with ulcerative (UC) remains unclear. Objective To study relationship between ADM and corticosteroid dependency UC. Design Using Clinical Practice Research Datalink we identified patients diagnosed UC 2005 2016. We grouped according to serotonin sel...

Zusammenfassung Nach einem Schlaganfall treten häufig relevante depressive Symptome (poststroke depression, PSD) auf, die in der klinischen Praxis übersehen oder unterschätzt werden. Die rasche Erkennung und angemessene Behandlung PSD sind für Rehabilitation Chance auf ein optimales funktionelles Ergebnis von entscheidender Bedeutung. Selektive Serotonin-Rückaufnahme-Inhibitoren (SSRI) sehr gut...

et al, our associated sample size was not sufficient to enable adequate statistical power to justify their investigation. We do, however, appreciate the significance of including data on infant mortality to more completely describe the effects of prenatal SSRI exposure on extreme clinical manifestations and the infant life prognosis. In accordance with this, we have included data on stillbirths...

BACKGROUND It is not clear if the frequency of deliberate self-harm (DSH) is the same in patients taking different pharmacological classes of antidepressant drugs. AIMS To compare the frequency of DSH in patients who had been prescribed a tricyclic antidepressant (TCA) or a selective serotonin reuptake inhibitor (SSRI) prior to the DSH event. METHOD This was a prospective study in 2776 cons...

p11, through unknown mechanisms, is required for behavioral and cellular responses to selective serotonin reuptake inhibitors (SSRIs). We show that SMARCA3, a chromatin-remodeling factor, is a target for the p11/annexin A2 heterotetrameric complex. Determination of the crystal structure indicates that SMARCA3 peptide binds to a hydrophobic pocket in the heterotetramer. Formation of this complex...

Dizziness is the most commonly reported symptom of abrupt discontinuation from the selective serotonin reuptake inhibitor (SSRI) category of antidepressants. The reported dizziness is exacerbated by even slight head movement, and therefore is likely to be vestibular in origin. The SSRIs most implicated are those with short half-lives and which are most selective for serotonin (as opposed to nor...

BACKGROUND Hypothesised associations between in utero exposure to selective serotonin reuptake inhibitors (SSRIs) and congenital anomalies, particularly congenital heart defects (CHD), remain controversial. We investigated the putative teratogenicity of SSRI prescription in the 91 days either side of first day of last menstrual period (LMP). METHODS AND FINDINGS Three population-based EUROCAT...