As water resources become further stressed due to increasing levels of societal demand, understanding the effect of climate and landuse change on various components of the water cycle is of strategic importance. In this study we used a previously developed hydrologic model of the Black Sea Catchment (BSC) to assess the impact of potential climate and landuse changes on the fresh water availabil...

Skeletal-related events (SREs) are a common complication of bone metastases, and have serious negative consequences for patients with castrate-resistant prostate cancer (CRPC). SREs can lead to severe pain, increased risk of death, increased health care costs and reduced quality of life. Until recently, zoledronic acid has been the sole standard of care for the prevention of SREs in men with CR...

Sleep-related experiences [Watson, D. (2001). Dissociations of the night: Individual differences in sleep-related experiences and their relation to dissociation and schizotypy. Journal of Abnormal Psychology, 110, 526-535] refer to a host of nocturnal altered-consciousness phenomena, including narcoleptic tendencies, nightmares, problem-solving dreams, waking dreams, and lucid dreams. In an att...

BACKGROUND Analyses of phase III trials showed that denosumab was superior to zoledronic acid (ZA) in preventing skeletal-related events (SREs) irrespective of age, history of SREs, or baseline pain status. This analysis assessed the risk of SREs across additional baseline characteristics. PATIENTS AND METHODS Patients (N = 5543) from three phase III trials who had breast cancer, prostate can...

The North Wyke Farm Platform (NWFP) provides data from the field- to the farm-scale, enabling the research community to address key issues in sustainable agriculture better and to test models that are capable of simulating soil, plant and animal processes involved in the systems. The tested models can then be used to simulate how agro-ecosystems will respond to changes in the environment and ma...

OBJECTIVE Skeletal-related events (SREs) among patients with bone metastases from lung cancer may be associated with considerable use of health care resources. We analyzed in- and outpatient hospital contacts in relation to SREs among all Danish lung cancer patients with bone metastases. METHODS For this cohort study, we used the Danish Cancer Registry and the Danish National Registry of Pati...

In this study, output of the Hadley Centre Regional Circulation Model (RCM) (HadRM3P, 0.44° × 0.44° resolution) was used as input to the Canadian Forest Fire Weather Index (FWI) for the present and 2 future IPCC climate scenarios (Special Report on Emissions Scenarios [SRES], A2 and B2 scenarios). The aim was to investigate the effects of climate change on fire risk (number of days with fire ri...

Until now ~30-40% of patients with advanced lung cancer develop bone metastases, but as the newer therapies are extending survival, the chance of developing bone metastases increases. Bone metastases cause skeletal-related events (SREs) such as pathologic fractures, spinal cord compression, radiation therapy or surgery to bone, or hypercalcemia, which can have debilitating consequences affectin...

BACKGROUND Skeletal related events (SREs) are common in men with metastatic prostate cancer (mPC). Various methods have been used to identify SREs from claims data. The objective of this study was to provide a framework for measuring SREs from claims and compare SRE prevalence and cumulative incidence estimates based on alternative approaches in men with mPC. METHODS Several claims-based appr...