نتایج جستجو برای: srebp1c
تعداد نتایج: 216 فیلتر نتایج به سال:
Retinoic acid (RA) is commonly used in vitro to differentiate stem cell populations including adult neural stem cells into neurons; however, the in vivo function of RA during adult neurogenesis remains largely unexplored. We found that depletion of RA in adult mice leads to significantly decreased neuronal differentiation within the granular cell layer of the dentate gyrus. RA contribution to n...
The PGC-1 family of coactivators stimulates the activity of certain transcription factors and nuclear receptors. Transcription factors in the sterol responsive element binding protein (SREBP) family are key regulators of the lipogenic genes in the liver. We show here that high-fat feeding, which induces hyperlipidemia and atherogenesis, stimulates the expression of both PGC-1beta and SREBP1c an...
The forkhead transcription factor Foxo1 regulates expression of genes involved in stress resistance and metabolism. To assess the contribution of Foxo1 to metabolic dysregulation during hepatic insulin resistance, we disrupted Foxo1 expression in the liver of mice lacking hepatic Irs1 and Irs2 (DKO mice). DKO mice were small and developed diabetes; analysis of the DKO-liver transcriptome identi...
Current research highlights the use of natural products or phytochemicals as drugs and functional additives to treat obesity with few side effects. Sargassum horneri (SH) Ulva australis (UA) are marine waste resources on Jeju Island, Republic Korea. In this study, we analyzed their antioxidant anti-obesity efficacies confirm potential additives. We prepared SH UA extracts using 80% ethanol obse...
Obesity and type 2 diabetes mellitus are major health concerns worldwide. In obese-type diabetic patients, the function of central brain clock in hypothalamus, as well rhythmicity white adipose tissue (WAT), reduced. To better understand how peripheral clocks (WAT) synchronized, we assessed importance for daily WAT rhythms. We compared gene expression rhythms core genes (Bmal1, Per2, Cry1, Cry2...
Liver lipid metabolism is under intricate temporal control by both the circadian clock and feeding. The interplay between these two mechanisms is not clear. Here we show that liver-specific depletion of nuclear receptors RORα and RORγ, key components of the molecular circadian clock, up-regulate expression of lipogenic genes only under fed conditions at Zeitgeber time 22 (ZT22) but not under fa...
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