The management of hormone-refractory prostate cancer represents a major challenge in the therapy of this tumor, and identification of novel androgen receptor antagonists is needed to render treatment more effective. We analyzed the activity of two novel androgen receptor antagonists, (S)-11 and (R)-9, in in vitro and in vivo experimental models of hormone-sensitive or castration-resistant prost...

a series of fluoroquinolone derivatives holding triazolidindione moieties have been synthesized and proved to be cytotoxic agents in vitro particularly against cancer cell lines (sknmc, mcf7, a2780-cp, sw48, a549, kb, ht-29, hepg 2 ). the cytotoxic activity was assessed using mtt colorimetric assay. our compounds had less cytotoxicity than doxorubicin in all studied cell lines.

Ninety-six crossbred steers were used in a 172-d feedlot growth performance trial to determine the effects of type processing on the comparative feeding value of barley in a 90% concentrate finishing diet. Treatments were: 1) steam-flaked corn (SFC; density = .31 kg/L); 2) dry-rolled barley (DRB; density = .39 kg/L); 3) steam-rolled barley, coarse roll (SRB-C, density = .39 kg/L); and 4) SRB, t...

background: natural products have gained importance recently for the treatment of obesity and its complications, partly because of the side effects of modern drugs.hence, we aimed to study and compare the effect of varying concentrations of momordicacharantiaon adipogenesis and adipolysis using 3t3-l1 pre-adipocyte cell lines. methods: 3t3-l1 pre-adipocytes were procured from the national cente...

Purpose: To determine the cytotoxic and antiviral potentials of Euphorbia milii var. splendens leaf against Peste des petits ruminants virus (PPRV).
 Methods: The methanol extract, as well n- hexane, chloroform, ethyl acetate, butanol fractions E. leaves were screened for activities PPRV using Vero cell line 3-(4,5-dimethylthiazol-2-yl)-2,diphenyltetrazolium bromide (MTT) assay.
 Resu...

BACKGROUND During the past few years, there has been an increasing interest among the Traditional and Folk medical practitioners of Sri Lanka in the use of a decoction prepared from Flueggea leucopyrus (Willd.) for treating various cancers including breast cancer. In the present study, the cytotoxicity of this decoction and its effects on Heat Shock Protein (HSP) expression and apoptosis were c...

Stabilized rice bran (SRB) is classified as a "functional food" because of its prebiotic characteristics. With increasing grain prices and the pressure to remove antibiotics from swine diets because of concern over antibiotic resistance, SRB was investigated as a nursery diet ingredient with and without the addition of antibiotics (ANT). Two hundred pigs were weaned at 21 d of age, blocked by B...

Sulforhodamine B (SRB), a common fluorescent dye, is often considered to be a purely hydrophilic molecule, having no impact on bulk or interfacial properties of aqueous solutions. This assumption is due to the high water solubility of SRB relative to most fluorescent probes. However, in the present study, we demonstrate that SRB is in fact an amphiphile, with the ability to adsorb at an air/wat...

Abundance and seasonal dynamics of sulfate-reducing bacteria (SRB), in general, and of extreme halophilic SRB (belonging to Desulfocella halophila) in particular, were examined in highly saline industrial wastewater evaporation ponds over a forty one month period. Industrial wastewater was sampled and the presence of SRB was determined by quantitative real-time PCR (qPCR) with a set of primers ...

This paper describes the architecture of the SDSC Storage Resource Broker (SRB). The SRB is middleware that provides applications a uniform API to access heterogeneous distributed storage resources including, lesys-tems, database systems, and archival storage systems. The SRB utilizes a metadata catalog service, MCAT, to provide a \collection"-oriented view of data. Thus, data items that belong...