Nuclear receptor (NR) coregulators are key modulators of hormone signaling. Discovery of steroid receptor RNA activator (SRA), a coregulator that is active as a RNA, transformed thinking in the field of hormone action. The subsequent identification of SRA-binding coregulator proteins, including p68, SHARP and more recently SLIRP, has provided important insight into SRA's mechanism of action and...

Serum resistance associated (SRA) gene has been found to confer resistance to the innate trypanolytic factor (TLF) found in normal human serum; thus allowing Trypanosoma brucei brucei to survive exposure to normal human serum. This study was carried out to examine the presence of SRA gene and identify the origin of T. b. rhodesiense isolates from three districts in Tanzania, namely Kibondo, Kas...

Spike rate adaptation (SRA) is a continuing change of responsiveness to ongoing stimuli, which is ubiquitous across species and levels of sensory systems. Under SRA, auditory responses to constant stimuli change over time, relaxing toward a long-term rate often over multiple timescales. With more variable stimuli, SRA causes the dependence of spike rate on sound pressure level to shift toward t...

CD36 has been reported to be a receptor for oxidized LDL (Ox-LDL). In our previous study, the uptake of Ox-LDL in CD36-deficient macrophages was reduced by approximately 50% compared with that in control macrophages, suggesting an important role of CD36 as a receptor for Ox-LDL in humans. In the current study, we examined the immunohistochemical localization of CD36 in human aorta in comparison...

In this chapter I follow the evolution of Joan Robinson’s appreciation of Sra¤a’s “critique of economic theory”over the years. My purpose is twofold: …rst, to construct a narrative based also on the archival …ndings; second, to shed some light on certain dividing issues–as we shall see in the …nal section– which impinged on the fortunes of the “Cambridge school”, in search of a clue to explain ...

INTRODUCTIO N SRA used the combination of two systems for the MUC–6 tasks : NameTag"" , a commercial software product that recognizes proper names and other key phrases in text ; and HASTEN, an experimental text extraction system that has been under development for only one year . For the Named Entity task, SRA adapted a subset of NameTag ' s capabilities to the MUC–6 specification . For the Te...

An indispensable role for the brain renin-angiotensin system (RAS) has been documented in most experimental animal models of hypertension. To identify the specific efferent pathway activated by the brain RAS that mediates hypertension, we examined the hypothesis that elevated arginine vasopressin (AVP) release is necessary for hypertension in a double-transgenic model of brain-specific RAS hype...

This paper proposed a new Static Resource Assignment (SRA) approach to enhance resource and bandwidth utilization in traditional Fractional Frequency Reuse (FFR) WiMAX Base Station (BS) which widely used in cellular network deployment to overcome the inter-cell interference. The new SRA FFR efficiently tackled the wastage of resources and bandwidth in traditional FFR. The work aimed to enhance ...

Loop-mediated isothermal amplification (LAMP) of DNA is a novel technique that rapidly amplifies target DNA under isothermal conditions. In the present study, a LAMP test was designed from the serum resistance-associated (SRA) gene of Trypanosoma brucei rhodesiense, the cause of the acute form of African sleeping sickness, and used to detect parasite DNA from processed and heat-treated infected...