Adverse events are generally tabulated and listed in statistical reports in randomized clinical trials. This paper introduces how to apply statistical methods to assess adverse events using SAS. In addition to the crude percentage (rate), adverse events are also adjusted by exposure time or multiple repeat. The paper also introduces the commonly used chi-square test and Fisher‟s exact test, and...

The construction of new explicit Runge–Kutta methods taking into account, not only their accuracy, but also the preservation of Quadratic Invariants (QIs) is studied. An expression of the error of conservation of a QI by a Runge–Kutta method is given, and a new six–stage formula with classical order four and seventh order of QI–conservation is obtained by choosing their coefficients so that the...