Many classes of antibacterial drugs are currently available for physicians to use, however the plan of antibiotic development has slowed during the last decade. The World Health Organization (WHO) has identified antimicrobial resistance as one of the 3 most important problems for human health. Antimicrobial resistance is a growing problem worldwide, especially in hospitals, where resistant orga...

Many classes of antibacterial drugs are currently available for physicians to use, however the plan of antibiotic development has slowed during the last decade. The World Health Organization (WHO) has identified antimicrobial resistance as one of the 3 most important problems for human health. Antimicrobial resistance is a growing problem worldwide, especially in hospitals, where resistant orga...

The spread of antibiotic resistance is currently a major threat to health that humanity is facing today. Novel multidrug and pandrug resistant bacteria are reported on a yearly basis, while the development of novel antibiotics is lacking. Focus to limit the spread of antibiotic resistance by reducing the usage of antibiotics in health care, veterinary applications, and meat production, have bee...

Drug resistance compromises control of malaria. Here, we show that resistance to a commonly used antimalarial medication, atovaquone, is apparently unable to spread. Atovaquone pressure selects parasites with mutations in cytochrome b, a respiratory protein with low but essential activity in the mammalian blood phase of the parasite life cycle. Resistance mutations rescue parasites from the dru...

Objective(s): Regarding the global burden of uropathogenic Escherichia coli (UPEC) infections, prevention and treatment of such infections play a significant role in healthcare management. The inordinate use of fluoroquinolones led to a worldwide spread of quinolone-resistant strains. Therefore, this study aimed to investigate mutations in codons 83 and 106 of gyrA gene in UPEC isolates in the ...