Propranolol (PL), a non-selective beta-blocker, is a cardiovascular drug widely used to treat hypertension. The present study was concerned with assessing the cytogenetic effects of this drug on Chinese hamster ovary (CHO) cell line. MTT assay was then carried out to determine the cytotoxicity index (IC50) of the drug. The IC50 value of PL was 0.43±0.02 mM. To investigate the clastogenic effect...

This paper deals with a proposal for joint modeling and process optimization split-plot designs analyzed through mixed response surface models. It addresses the following main issues: i) building of responsesurface model multiple situation, by defining only one which specific coefficients areincluded studying association among responses; ii) considering fixed as well random effects within conte...

A first principles model of a cement grinding circuit is developed for the purpose of multi-variable model predictive control (MPC). The model is based on a series of mixed flow reactors with an ideal screen to model flow between the two chambers in the ball mill. The separator is modelled by efficiency curves. Breakage of the particles is modelled as a first order process in terms of functions...

Cutting tools are widely used in manufacturing processes and drilling is the most commonly used machining process. Although drill-bits used in drilling may not be expensive, their breakage can cause damage to expensive work piece being drilled and at the same time has major impact on productivity. Predicting drill-bit breakage, therefore, is important in reducing cost and improving productivity...

BACKGROUND Implant breakage after the fixation of traumatic fractures is rare; however, when it occurs, it is debilitating for the patients and a challenge for surgeons. The purpose of this study was to analyze and identify the independent risk factors for implant breakage of traumatic fractures treated with plate osteosynthesis. METHODS We reviewed the medical records of patients with a frac...

the rotor of enegelberg whitener was equipped with a screw conveyor to reduce broken rice percentage. according to preliminary experiments this modification could reduce broken rice percentage about 2.5%. further experiment was performed to determine the effect of rotor speeds and blade positions on white rice quality. to do this, five rotor speeds, consisting 500, 600, 700, 800 and 900 r.p.m a...

Composite or closely linked maize (Zea mays) Ac/Ds transposable elements can induce chromosome breakage, but the precise configurations of Ac/Ds elements that can lead to chromosome breakage are not completely defined. Here, we determined the structures and chromosome breakage properties of 15 maize p1 alleles: each allele contains a fixed fractured Ac (fAc) element and a closely linked full-le...

Plates of austenitic stainless steel are often used in orthopedic surgery for fixing ends of the broken bones and for repairing fractures. The paper analyzes a premature breakage of six plates for fixing broken bones with different patients during their recovery. Each plate's breakage can induce serious aftermaths such as a new surgery, unexpected undesired complications and a prolonged healing...

The rigid-body spring model (RBSM) theory was incorporated into a model as a discrete method for analysing problems of limit, such as the stress distribution on the condyle. The purpose of this study was to evaluate the two-dimensional RBSM for determining stress on the temporomandibular joint (TMJ) in patients after orthognathic surgery. Thirty-two patients (five males and 27 females, mean age...

Detection of tool breakage is very important for automated machining operations. This paper presents a negative-selection algorithm for tool breakage detection. The method is inspired by the defense mechanism of the immune system, which discriminates between self and non-self. Here self is deened to be normal cutting operations and non-self is any deviation beyond allowable variation of the cut...