the distinction between malignant and benign pheochromocytoma has always been a diagnostic challenge over the last decades. to date, the only reliable criterion is metastasis. the aim of the present study was to investigate the possible expression of pituitary-tumor transforming gene (pttg1) and retinoblastoma (rb) in benign and malignant pheochromocytoma. paraffin blocks of 44 and 11 patients ...

MAD2 inhibits the anaphase-promoting complex when chromosomes are unattached to the mitotic spindle. It acts as a tumor suppressor gene because MAD2+/-cells enter anaphase early and display chromosome instability, leading to the formation of lung tumors in mice. Complete MAD2 inactivation has not been identified in human tumors, although partial defects are prevalent. By employing RNA interfere...

Intranodal palisaded myofibroblastoma (IPM) is a kind of mesenchymal tumor with benign behaviour. The origin this differentiated smooth muscle cells and myofibroblasts. This rare entity differential diagnosis from malignant tumors important for clinicians pathologists. etiology has not been explained adequately. Age range between 2nd 8th decades the life it seen more frequently in males. Inguin...

BACKGROUND Carcinosarcomas, also known as spindle cell carcinomas, are rare and highly aggressive tumors characterized by dual histologic differentiation of squamous cell and mesenchymal cell tumors. Occurrence of carcinosarcoma in maxillary sinus is very rare, with only 11 cases reported since 1957. The small number of reported cases creates an obstacle to the increased understanding of the be...

The expression of the cell-cell adhesion molecules E- and P-cadherin has been analyzed in seven mouse epidermal keratinocyte cell lines representative of different stages of epidermal carcinogenesis. An inverse correlation between the amount of E-cadherin protein and tumorigenicity of the cell lines has been found, together with a complete absence of E-cadherin protein and mRNA expression in th...

Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome in which secretes high molecular weight (“big”) IGF-2, causing hypoglycemia. Big IGF-2 product of abnormal processing precursors with defective gene transcription and expression. Tumors involved are usually mesenchymal, vascular, or epithelial origin have burden. We report an unusual case NICTH patient concomitant spind...

Trop2, an oncogenic cell surface protein under investigation as a therapeutic target, is commonly overexpressed in several epithelial tumor types yet its function in tumor biology remains relatively unexplored. To investigate the role of Trop2 in epithelial carcinogenesis, we generated Trop2(-/-) mice, which are viable and possess a normal lifespan. Contrary to expectations, Trop2 loss fails to...

p63 is a p53 homolog that is expressed in various normal epithelial tissues and epithelial malignancies. Its expression in mesenchymal lesions has not been examined in depth; therefore, we studied p63 expression by immunohistochemical analysis in 650 soft tissue tumors. We found that p63 expression is limited in soft tissue tumors. The majority of tumors studied were p63-, including all cases o...

Background Primary omental tumors are uncommon, and fibromas account for 2% of these tumors. Due to the low incidence limited relevant literature, it is challenging clinicians make an accurate diagnosis this condition, especially before surgery. Case summary A 30-year-old man was admitted hospital because a left epididymal mass with vague discomfort more than 1 mo. physical examination performe...

Trop2, an oncogenic cell surface protein under investigation as a therapeutic target, is commonly overexpressed in several epithelial tumor types yet its function in tumor biology remains relatively unexplored. To investigate the role of Trop2 in epithelial carcinogenesis, we generated Trop2 / mice, which are viable and possess a normal lifespan. Contrary to expectations, Trop2 loss fails to su...