Netilmicin (Sch 20569), a semisynthetic aminoglycoside related to gentamicin C(1a), was evaluated in vitro in agar dilution testing against 224 different clinical isolates of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa in parallel with amikacin, gentamicin, sisomicin, and tobramycin. Netilmicin showed a very high degree of activity against gentamicin-resistant organisms, ...

Information derived from a study of 'isolated' CH stretching frequencies, measured in partially deuterated organic and organemetallic compounds, is reviewed. This includes CH bond lengths . and dissociation energies, and HCH angles in methyl groups, Excellent agreement is found between CH bond length differences predicted from VCH's values and those calculated by ab initio methods. V'sCH data a...

Arecaceae Schultz-Sch. (Palmae Juss.), a member of the monocotyledon group, is considered one of the oldest extant angiosperm families on Earth. This family is highly valuable because of its species diversity, its occurrence in a wide range of habitats, and its status as an integral part of the culture and the family-based economy of many traditional and nontraditional communities. The main obj...

We propose a first order modal logic, the QS?E-logic, obtained by adding to the well-known first order modal logic QS4 a rigidity axiom sch?mas : A -> O A, where A denotes a basic formula. In this logic, the possibility entails the possibility of extending a given classical first order model. This allows us to express some impor? tant concepts of classical model theory, such as existential comp...

During the course of an investigation on the cultural conditions affecting production of amylase by Bacillus macerans, it was observed that aeration resulted in an increase in amylase yields and in an appreciable decrease in the time of incubation necessary for its production. A 5 per cent rolled oats medium buffered with 2 per cent calcium carbonate, recommended as most suitable for amvlase pr...

A new species of Actinoplanes, which has been deposited with the designation NRRL 5325 at the Northern Utilization Research and Development Division of the U. S. Department of Agriculture, produces a polyene antifungal complex designated as Sch 16656. The complex, consisting of one major and three minor components, is isolated from the fermentation broth by a solvent extraction procedure and pu...

Antimicrobial susceptibility to sisomicin and netilmicin (Sch 20569) was determined on 164 clinical isolates using a broth microdilution method. Sisomicin was active against 86.1%, and netilmicin against 96.4%, of the isolates. In addition, netilmicin was active against 93.7% of the strains that were resistant to gentamicin, kanamycin, tobramycin, and sisomicin.

The relative nephrotoxicities of netilmicin (Sch 20569) and gentamicin were compared in rats at doses of 30, 60, 90, and 120 mg/kg per day for 15 days. Both drugs caused proteinuria and a decrease in urine osmolality; however, netilmicin produced significantly less changes at all doses than gentamicin. Whereas gentamicin resulted in a decline in creatinine clearance at all doses, netilmicin fai...

(4E,8E,10E)-9-Methyl-4,8,10-sphingatrienine, a core component of marine sphingolipids, was synthesised for the first time using a copper(I)-mediated 1,2-metallate rearrangement of a lithiated glycal as a key step. It was converted to phalluside-1, a cerebroside isolated from the ascidian Phallusia fumigate. By an analogous route, (4E,8E)-9-methyl-4,8-sphingadiene was synthesised and converted t...

1. Simultaneous and continuous measurements of changes in CO2 and 02 concentrations in glucose-metabolizing yeast suspensions by mass spectrometry enabled a study of the Pasteur effect (aerobic inhibition of glycolysis) in Saccharomyces uvarum and Schizosaccharomyces pombe. 2. A different control mechanism operates in Candida utilis to give a damped oscillation after the anaerobic-aerobic trans...