background: the present study was designed to evaluate the secondary microglial activation processes after spinal cord injury (sci). methods: a quantitative histological study was performed to determine ed-1 positive cells, glial cell density, and cavitation size in untreated sci rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4. results: the results of glial cell quantification along the 4900...

objective(s):spinal cord injury (sci) often causes serious and irreversible neurological deficit leading to disability or impairment of normal physical activity. atomoxetine, a selective norepinephrine transporter (net) inhibitor has gained much attention in the field of the neurodevelopmental disorder, but its effect on sci has not been evaluated. the present study has been undertaken to inves...

Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract....

objective(s): ischemia/reperfusion (i/r) injury of spinal cord is leading to the paraplegia observed. in this study, we investigated the protective effect of the saffron extract on spinal cord i/r injury. materials and methods: thirty five male sprague-dawley rats were divided into 5 groups: intact, sham surgery, normal saline (ns), low dose saffron aqua extract, high dose saffron aqua extract....

introduction spinal tumours may be classified in three groups: 1) extradural, 2) intradural extramedullary and 3) intramedullary spinal cord tumours. intradural extramedullary tumours arise from the leptomeninges or nerve roots and include schwannomas. a schwannoma is usually a firm grey-whitish tumour growing near a nerve trunk or ramus. it can be separated from the nerve without damaging neur...

Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to r...

One of the most important factors responsible for axonal degeneration following spinal cord trauma is ischemia produced by cord compression. Previous studies have revealed that omental transposition upon the injured site of the spinal cord could be beneficial in the induction of partial improvement of neuroelectrical and motor function in laboratory animals. The purpose of this study is to...

Background and aims: One of the most common injuries around the world is the traumatic injury of the spine and spinal cord with unknown worldwide situation of traumatic spinal cord injury (TSCI) affecting on the effectiveness of preventive policy programs. In addition, because of possibility of making paralysis, the potential injury to the spine could be one of the most importa...