Objective(s) Four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. The effects of 5a and 5b on angiotensin receptors (AT') and L-type calcium channels were investigated on isolated rat aorta. Materials and Methods Aortic rings were pre-contracted with 1 pM Angiotensin II or 80 mM KCl and relaxant effects of losartan, nifedipine, 5a and...

objective(s) four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. the effects of 5a and 5b on angiotensin receptors (at') and l-type calcium channels were investigated on isolated rat aorta. materials and methods aortic rings were pre-contracted with 1 pm angiotensin ii or 80 mm kcl and relaxant effects of losartan, nifedipine, 5a a...

A simple empirical method is proposed for computing the backwater level different bridge shapes and crossings in compound channels. series of parametric studies was conducted on influence...

2014 A statistical model calculation of the compound nuclear contribution to the 12C + 20Ne elastic scattering reaction has been performed. The results indicate that compound elastic scattering may account for most of the cross-section observed at angles larger than 90° c.m., supporting the proposal that the optical potential for the 12C + 20Ne system is considerably more absorptive than for th...