Closely related species that have previously inhabited geographically separated ranges are hybridizing at an increasing rate due to human disruptions. These human-mediated hybrid zones can be used study reproductive isolation between secondary contact, including examining locus-specific rates of introgression. Introgression is expected heterogenous across the genome, reflecting variation in sel...

background: adequate self-care in diabetes causes quality of life promotion and decreases the number of inpatient cases. the health locus of control theory is used to assess adherence to diabetes regimen in some studies in developed countries. the purpose of this study was to determine the status of diabetes locus of control in a sample of diabetic patients in iran and investigation of it's rel...

conclusions our findings indicate that heterogeneity at +2109 locus of ifn-γ gene but not at +874 locus could interfere with successful therapy in patients infected with hcv genotype 1. results of 158 patients, 110 (69.5%) subjects achieved svr and 48 (30.5%) subjects did not respond to therapy. the frequency of aa genotype (p = 0.001; or: 11.2; ci: 2.26-63.21) and a allele (p = 0.01; or: 3.23;...

Specific-locus experiments have previously shown melphalan to be mutagenic in all male germ-cell stages tested and particularly so in early spermatids. All but 2 of 24 specific-locus mutations recovered were tested genetically, cytogenetically, and/or molecularly. At least 12 of 15 tested mutations recovered from postspermatogonial stages but only 1 of 7 mutations recovered from stem-cell or di...