Laboratory models show that the beta-blocker, propranolol, can inhibit norepinephrine-induced breast cancer cell migration. We hypothesised that breast cancer patients receiving beta-blockers for hypertension would show reduced metastasis and improved clinical outcome. Three patient subgroups were identified from the medical records of 466 consecutive female patients (median age 57, range 28-71...

Although small-conductance Ca(2+)-activated K(+) (SK) channels and various types of voltage-gated Ca(2+) (Cav) channels have been described in midbrain dopaminergic neurons, the nature of their interactions is unclear. More particularly, the role of various Cav channel types in either promoting irregularity of firing (by generating an inward current during SK channel blockade) or promoting regu...

Kalsiyum kanal blokerleri toplumda çok yaygın olarak kullanılan bir kardiyovasküler ilaç gurubudur. Sık reçete edilmesi, kolay ulaşılabilir olması nedeniyle özkıyım amacıyla yüksek doz alımlarına acil servislerde sıklıkla rastlanılmaktadır. Aşırı alımları dirençli şok, hayatı tehdit eden bradidisritmi, kardiyojenik çoklu organ yetmezliği ölüme sebebiyet verebilir. Erken tanı ve erken tedavi hay...

INTRODUCTION Few studies have examined outcomes and potential complications among glaucoma patients who are prescribed topical beta-blockers. This study examined resource usage (number of GP visits and hospitalizations) and diagnoses of respiratory or cardiovascular conditions among glaucoma patients prescribed beta-blockers compared to patients not prescribed beta-blockers. METHODS A retrosp...

At early stages of brain development, GABA plays a dual role. It fulfills important trophic functions and provides a major excitatory drive for the immature neuronal network. Here, we investigated whether GABA itself can limit the strength of excitatory GABAergic synapses on Cajal-Retzius (CR) cells in sagittal slices from the mouse visual cortex. (2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino...