The present study deals with characterization of dispersions of a poorly water-soluble drug, celecoxib (CLX) in polyvinyl caprolactame–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus® (SOL)) prepared by different techniques. Dispersions of CLX in SOL at different ratios (2:1, 1:1, 1:2, 1:4 and 1:6) were prepared by spray drying, conventional solvent evaporation and melting metho...

The present study deals with characterization of dispersions of a poorly water-soluble drug, celecoxib (CLX) in polyvinyl caprolactame–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus® (SOL)) prepared by different techniques. Dispersions of CLX in SOL at different ratios (2:1, 1:1, 1:2, 1:4 and 1:6) were prepared by spray drying, conventional solvent evaporation and melting metho...

The aim of present study was to improve the solubility Rasagilline mesylate, an Atypical Antipsychotic agent which is BCS Class III drug and thus has very low hence poor bioavailability owing less absorption. Moreover mesylate a bitter taste. Thus in attempt made taste mask oral by formulating into solid dispersion then formulate dispersions Fast Dissolving Tablets. Solid Dispersions were formu...

Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three for...

Introduction. N. Blokhin National Medical Research Center of Oncology the Ministry Health Russia synthesized an original derivative indolocarbazole with carbohydrate residue xylose, which has a pronounced cytotoxic and anti-angiogenic activity. The substance LCS-1269 is amorphous powder that almost insoluble in water, causes difficulties development injectable dosage form (IDP). To solve this p...