Poorly solubility in water of many newly developed high-potential drugs is an obstacle in formulation development. The aim of this study was to increase the solubility of Lamotrigine which is a poorly soluble drug and comes under BCS class-II by using solid dispersion technique. Lamotrigine, PEG 4000 and PVPK-30 solid dispersion was prepared by solvent evaporation method and the formulation was...

the human mdr1 gene encodes for a p-glycoprotein (pgp), which acts as an efflux pump that transports a large variety of substrates from the inside of cells to the outside until protection against xenobiotics. the g2677t/a polymorphism in exon 21 is associated with pgp expression and function in humans. the present study was aimed to determine the frequencies of this polymorphism in a healthy po...

The present study aims to experiment the solid dispersion of poorly water soluble drug itraconazole as model drug by spray drying method with the use of PEG/HPMC polymer blends, the influence of polymer compatibility on the degree of molecular dispersion of itraconazole solid dispersions are prepared by ternary mixing and polymer blends are also evaluated for DSC, XRD and in vitro dissolution t...

Curcumin is coming from the Curcuma longa which gives golden color and have the biological importance. As per the survey it is water insoluble, the poor solubility and wettability of curcumin leads to poor dissolution and hence shows poor bioavailability. The present study is aimed at increasing solubility of drug using solid dispersion technique. The solid binary systems were prepared using di...

Solid Dispersions were prepared by solvent evaporation technique using microcrystalline cellulose, PEG 4000, PEG 6000, PVP-K30 and Gelucire 50/13. Further objective of the project was to develop fast release surface solid dispersion of glibenclamide and compressed at low pressure to form fast-melting pharmaceutical tablet. In this study, we used sodium starch glycolate for mouth dissolving natu...

A solid dispersion of the drug can be made using a polymer carrier to improve solubility. Generally, drugs become amorphized when solid dispersion is formed using a polymer carrier. In such high energy conditions, the solubility of the drug molecule is increased. We previously prepared solid dispersion using a spray-drying technique and reported its solubility and crystallinity. In this study, ...