The parameters for a representative two-body Morse potential are determined for the solidified inert gases by fitting to O'K solid data. This is done using first the harmonic approximation and subsequently the first-order self-consistent harmonic approximation, which provides an upper limit to the anharmonic correction, to describe the solid at O'K. On comparing the two cases, the effect on the...

INTRODUCTION Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by a solid dispersion technique. METHODS Solid dispersion of prednisolone was prepared with PEG 6000 or different carbohydrates such as lactose a...

Solid dispersions traditionally have been used as effective methods to improve the dissolution properties and bioavailability of poorly water-soluble drugs. Furosemide a loop diuretic belonging to Biopharmaceutical Classification System (BCS) Class IV, has very poor water solubility. The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, ...

The aim of this investigation was to improve the dissolution properties of the water-insoluble drug ezetimibe (EZE) and potentially improve bioavailability. A combination of melt and adsorption techniques was employed for the preparation of solid dispersions. PEG 4000, PEG 6000, and Gelucire 44/14 were used as hydrophilic carriers, and lactose monohydrate was used as an adsorbent. Phase solubil...

the effect of mixing on rheological behavior of 6% wt epoxy-clay nanocomposites was studied. the mixing processes were carried out by low shear mixer, homogenizer and ultrasonic and combination of different mixing techniques at medium and maximum power. all these methods led to intercalated structure. the xrd results showed that the ultrasonic has the best effect on dispersion while a low shear...