the nodular thyroid diseas is one of the most common disturbances o the thyroid gland wheras malignant tumors are among the most unusual entities of it. not only differentiation of these two spectra but also the problems to achieve early diagnosis and treatment, have been a matter of concern, research, and controversy. two hundred patients were assessed at the cancer institute of imam khomeini ...

BACKGROUND Although second primary cancers are a leading cause of death among men with testicular cancer, few studies have quantified risks among long-term survivors. METHODS Within 14 population-based tumor registries in Europe and North America (1943-2001), we identified 40,576 1-year survivors of testicular cancer and ascertained data on any new incident solid tumors among these patients. ...

Accumulated studies have provided controversial evidences of the association between Forkhead Box M1 (FOXM1) expression and survival of human solid tumors. To address this inconsistency, we performed a meta-analysis with 23 studies identified from PubMed and Medline. We found elevated FOXM1-protein expression was significantly associated with worse 3-year overall survival (OS) (OR = 3.30, 95% C...

MicroRNA 200c is a microRNA 200 family member that plays an important role in regulation of the epithelial- to-mesenchymal transition (EMT). The prognostic value of microRNA 200c in solid tumors remains controversial because of inconsistent data. Here, we report a meta-analysis of the association of microRNA 200c expression and survival in patients with solid tumors. Pubmed was searched up to N...

Cox TR, Erler JT. Lysyl oxidase in colorectal cancer. Am J Physiol Gastrointest Liver Physiol 305: G659–G666, 2013. First published September 5, 2013; doi:10.1152/ajpgi.00425.2012.—Colorectal cancer is the third most prevalent form of cancer worldwide and fourth-leading cause of cancer-related mortality, leading to 600,000 deaths annually, predominantly affecting the developed world. Lysyl oxid...

Abstract Background Solid pseudo-papillary tumor of the pancreas (SPTP) is a rare disease with a low malignant potential. Though it shows low malignant potential 10% to 15% of the cases show aggressive behavior with metastatic involvement of the liver. The symptoms include abdominal discomfort and abdominal pain. It is very rare in early years of age. This is the case of a 10 year old girl wi...

Background. Small-sized lung cancers showing a wide area of ground-grass opacity (GGO) on thin-section computed tomography (CT) are considered to be a good candidate for limited surgical resection, because of its minimally invasive nature. On the other hand, the validity of limited resection for radiologically “solid” tumors is still controversial in small-sized non-small cell lung carcinoma. M...

Oncolytic Bacteria In article number 2301679, Eijiro Miyako and co-workers discover the microbial consortium AUN composed of Proteus mirabilis (A-gyo) Rhodopseudomonas palustris (UN-gyo) from solid tumors. The can trigger immune system to eliminate cancer cells, provoking strong anticancer responses in various mouse models cancer. has promising potential for innovative theranostics.

The present era of oncology is characterized by manifold and rapid advances in the management of solid tumors. New treatment modalities and new agents such as neo-adjuvant chemoradiation in rectal cancer or targeted therapies in non-small cell lung cancer have not only remarkably prolonged the survival, but also improved the quality of life of an ever increasing number of patients with solid ne...

Cancer is a complex disease that involves aberrant gene expression regulation. Discriminating the modified expression patterns driving tumor biology from the many that have no or little contribution is important for understanding cancer molecular basis. Recurrent deregulation patterns observed in multiple cancer types are enriched for such driver events. Here, we studied splicing alterations in...