A 15 days old female baby presented with a 6 x 7 cm reddish lump with irregular margins on her right scapular region, since birth. Histopathology and immunohistochemistry of excised tissue revealed it to be soft tissue Ewing's sarcoma. Postoperatively, she received only one dose of chemotherapy but could not survive and expired at the age of one month.

Dr Robinson is Senior Lecturer in Clinical Oncology, in the Section of Clinical Oncology, at Weston Park Hospital, Shef® eld, UK. He has been involved in the ® eld of sarcomas for 10 years and runs a sarcoma clinic at the above hospital. His other main area of interest is the treatment of head and neck cancer. He is chairman of the Local Treatment Group of the EORTC Soft Tissue and Bone Sarcoma...

Progress has been made • The understanding of the biology (cytoand molecular genetics) of the tumour has improved. The identification of the translocation in alveolar RMS has been important, particularly in the identification of those patients who have tumours with a poorer outlook. The t(2;13) and t(1:13) are known to be associated with alveolar disease the former carrying the poorer prognosis...

  Chloroma or granulocytic sarcoma (GS) is a malignant neoplasm of myeloid lineage that occur in a variety of anatomic sites other than the bone marrow including soft tissue, bone, lymph node, nasal fossa, skin and sometime in the orbit. In the subconjunctiva it is rarely reported. A 4-year-old girl with a history of treated acute myelogenous leukemia was referred to Farabi Eye Hospital, Tehra...

Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-Kras(G12D); Trp53(Flox/Flox) mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 i...

Reprint requests to: Dr. Michael Mu Huo Teng Department of Radiology, Taipei Veterans General Hospital. No. 201, Shih Pai Road, Taipei 112, Taiwan, R.O.C. Synovial sarcoma is a rare and aggressive soft tissue tumor with extensive metastatic potential. It accounts between 8 and 10% of all soft tissue malignancies. Involvement of the head and neck region is relatively rare. We report a case of sy...

Ifosfamide, a congener of Cyclophosphamide, was originally introduced into clinical practice in 1971, but has not been widely used because of severe dose limiting urotoxicity, particularly when used as a single agent in large doses. A resurgence of interest in Ifosfamide followed the demonstration that urotoxicity could be lessened or abrogated by fractionated administration or, more effectivel...

These NCCN Guidelines Insights highlight the important updates to the NCCN Guidelines for Soft Tissue Sarcoma (STS) specific to the role of radiation therapy in the management of patients with retroperitoneal/intra-abdominal STS. The guidelines have also included recommendations for genetic testing and counseling for patients with a clinical and/or family history of genetic cancer syndromes ass...