Sodium valproate is a commonly used antiseizure drug with broad indications for different seizuretypes and epilepsy syndromes. Well-recognised side effects include weight gain, tremor, dizziness, and unsteadiness. Non-hyperammonaemic parkinsonism, with or without cognitive impairment, is a rare adverse effect of sodium valproate. We present the case of a sixty year-old lady with a generalized s...

to compare the effects of topiramate versus valproate sodium as an add-on therapy to a combination of lithium and risperidone (li+ris) on body weight and serum lipid profile in children and adolescents with bipolar disorder.in a single-blind randomized clinical trial, thirty children and adolescents with bipolar disorder type i in the manic or mixed phase, treated with the combination of li+ris...

This essay was submitted for the Royal College of Psychiatry's perinatal psychiatry medical student essay prize in 2017. The essay considers the choices available to women with bipolar disorder who become pregnant while taking sodium valproate to treat mania or for mood stabilisation. The implications of three options are considered: to stop all treatment, to switch to a different mood stabilis...

2011;76;383 Neurology R. Shallcross, R.L. Bromley, B. Irwin, et al. sodium valproate Child development following in utero exposure : Levetiracetam vs May 5, 2011 This information is current as of http://www.neurology.org/content/76/4/383.full.html located on the World Wide Web at: The online version of this article, along with updated information and services, is rights reserved. Print ISSN: 00...

introduction: epilepsy is a clinical syndrome in which seizures have a tendency to recur. sodium valproate is the most effective drug in the treatment of all types of generalized seizures. finding the optimal dosage (the lowest effective dose) of sodium valproate is a real challenge to all neurologists. in this study, a new approach based on adaptive neuro-fuzzy inference system (anfis) was pre...

Aim: We compared the clinical efficacy and subsequent changes in dosages of concomitantly used psychotropic drugs with lamotrigine and sodium valproate therapy in Alzheimer’s disease (AD) with Behavioral and Psychological Symptoms on Dementia (BPSD). Methods: This study was a 16-week, retrospective, open-label study. The 45 subjects were inpatients. The outcome measures assessed were BPSD and c...