OBJECTIVE To compare venous thrombosis rates among animals treated with aspirin, clopidogrel bisulfate, and ketorolac tromethamine using an anastomotic "tuck" model. DESIGN Single-blind randomized animal study. SETTING An animal laboratory at a tertiary care academic referral center. SUBJECTS Forty-two retired Lewis breeder rats divided into 3 equal groups. INTERVENTIONS Before surgical...

Density functional theory has been used to investigate the thermodynamics and activation barriers associated with the direct oxidation of methane to acetic acid catalyzed by Pd2+ cation in concentrated sulfuric acid. Pd2+ cations in such solutions are ligated by two bisulfate anions and by one or two molecules of sulfuric acid. Methane oxidation is initiated by the addition of CH4 across one of...

Objectives Transforming growth factor alpha (TGF-α) has been shown to modulate the gastric acid secretion. Therefore, the aim of the present study was to investigate the effect of sodium hydrosulfide (NaHS) on TGF-α expression in gastric mucosa in rats. Materials and Methods Eighteen rats were randomly divided into 3 groups (6 per group). To determine the effect of NaHS on gene and protein ex...

Quantum chemical calculations were employed to model the interactions of the [(NH4(+))4(HSO4(-))4] ammonium bisulfate cluster with one or more molecular products of monoterpene oxidation. A strong interaction was found between the bisulfate ion of this cluster and a carboxylic acid, aldehyde, or ketone functionality of the organic molecule. Free energies of adsorption for carboxylic acids were ...

Stimulated by the report of high-yield, low-temperature catalytic conversion of methane to methyl bisulfate (Periana et al., Science 1998, 280, 560), we studied the relative stability and reaction mechanism of the Pt(NH3)2Cl2 and Pt(bpym)Cl2 complexes in concentrated sulfuric acid. We find that the mechanism involves a series of steps beginning with C-H activation to form an intermediate ion-pa...

A simple, sensitive, and specific reversed phase liquid chromatographic method was developed and validated for simultaneous quantification of clopidogrel, its carboxylic acid metabolite, and atorvastatin in human serum. Plasma samples were deproteinized with acetonitrile and ibuprofen was chosen as internal standard. Chromatographic separation was performed on an BDS Hypersil C18 column (250 × ...