Endocytosed (glyco)sphingolipids are degraded, together with other membrane lipids in a stepwise fashion by endolysosomal enzymes with the help of small lipid binding proteins, the sphingolipid activator proteins (SAPs), at the surface of intraluminal lysosomal vesicles. Inherited defects in a sphingolipid-degrading enzyme or SAP cause the accumulation of the corresponding lipid substrates, inc...

MicroRNA has been shown to be essential for correct cardiovascular development and physiology in a number of recent reports. Studies have also started to characterize the link between specific microRNAs and aspects of pathogenesis--such as chamber morphogenesis, conduction, and contraction--and between microRNA expression signatures and pathological cardiac phenotypes--such as hypertrophy, isch...

The pivotal problem of comorbidity research lies in the psychometric foundation it rests on, that is, latent variable theory, in which a mental disorder is viewed as a latent variable that causes a constellation of symptoms. From this perspective, comorbidity is a (bi)directional relationship between multiple latent variables. We argue that such a latent variable perspective encounters serious ...

OBJECTIVES To determine the 12-month prevalence of substance-use disorders and psychological morbidity in an Australian arrestee population. DESIGN Cross-sectional descriptive study. PARTICIPANTS AND SETTING 288 police arrestees at the Brisbane City Police Watch House in February and March 2001. OUTCOME MEASURES Prevalence of drug and alcohol disorders; psychological "caseness" according ...

Dental patients with special needs are people with different systemic diseases, multiple disorders or severe physical and/or mental disabilities. A Medline search was made, yielding a total of 29 articles that served as the basis for this study, which offers a brief description of the dental intervention protocols in medically compromised patients. Dental treatment in patients with special need...