نتایج جستجو برای: sobp
تعداد نتایج: 108 فیلتر نتایج به سال:
Following the promising results of [1], further phantom experiments have been performed at GSI in order to address the feasibility and accuracy of in-beam positron emission tomography (PET) for proton therapy. For the most challenging issue of range monitoring it has been demonstrated for mono-energetic as well as for spread-out Bragg peak (SOBP) irradiation that range differences of about 0.9m...
Proton therapy is a common form of external radiation therapy based on the manipulation of Bragg peak of this beam, it can treat the tumor by delivering high levels of doses to it, while protecting surrounding healthy tissues against radiation. In this work, the dose distribution of proton and secondary particles such as neutrons, photons, electrons and positrons in gastric cancer proton therap...
The thymus gland is an endocrine gland that plays an important role in the body’s immunity. Thymus gland cancer happens very rarely and one treatment way is radiation therapy. Due to the location of this gland and its proximity to the sensitive organs, radiation therapy of thymus gland cancer will bring the risk of side effects. In this paper, a Mird phantom is simulated and a modulator and ran...
با وجود پیشرفت های زیاد در پرتو درمانی، اُفت نمایی فوتون های اولیه بواسطه ی ماهیت برهمکنش فوتون با ماده به عنوان اصلی ترین چالش باقی مانده است. فوتون ها برد خوش- تعریفی ندارند و دز آن ها به طور نمایی کاهش می-یابد، لذا، اندام های قبل و پس از ناحیه ی مورد نظر، دز قابل توجهی دریافت می کنند. امروزه، تکنیک های جدید بر پایه باریکه های ذرات باردار در بسیاری مراکز پرتو درمانی در سراسر جهان گسترش یافته ا...
BACKGROUND Aim of this study was to evaluate the relative biological effectiveness (RBE) of carbon (12C) and oxygen ion (16O)-irradiation applied in the raster-scanning technique at the Heidelberg Ion beam Therapy center (HIT) based on clonogenic survival in hepatocellular carcinoma cell lines compared to photon irradiation. METHODS Four human HCC lines Hep3B, PLC, HepG2 and HUH7 were irradia...
We experimentally evaluated the proton beam dose reproducibility, sensitivity, angular dependence and depth-dose relationships for a new Metal Oxide Semiconductor Field Effect Transistor (MOSFET) detector. The detector was fabricated with a thinner oxide layer and was operated at high-bias voltages. In order to accurately measure dose distributions, we developed a practical method for correctin...
PURPOSE This work investigated the proton tissue-equivalence of various 3D printed materials. METHODS Three 3D printers were used to create 5 cm cubic phantoms made of different plastics with varying percentages of infill. White resin, polylactic acid (PLA), and NinjaFlex plastics were used. The infills ranged from 15% to 100%. Each phantom was scanned with a CT scanner to obtain the HU value...
BACKGROUND Patients with Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) positive lung cancer are sensitive to ALK-kinase inhibitors. TAE684 is a potent second generation ALK inhibitor that overcomes Crizotinib resistance. Radiotherapy is an integral therapeutic component of locally advanced lung cancer. Therefore, we sought to investigate the effects of...
PURPOSE To evaluate the effects of overlapping dose volumes for varying field arrangements in two formulations of PRESAGE®: one intended for, and irradiated with, proton beams and the other photon beams. METHODS For each treatment modality (photon, proton), three overlapping field setups were performed. These included a stationary dosimeter irradiated over six fractions, a dosimeter shifted l...
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