BACKGROUND Olfactory identification was reported to be better among PD (Parkinson disease) patients with Parkin mutations, but previous studies didn't eliminate the interference of other PD related genes on olfaction, and whether olfaction of Parkin mutations patients was better in Chinese population was still unknown. OBJECTIVE To assess olfaction function among PD patients with Parkin mutat...

BACKGROUND The aim of the study was to determine the influence of DRD2 gene polymorphisms in exon 8 G/A (rs 6276) in the promoter region -141 C Ins/Del (rs1799732) and the influence of ANKK-1 gene Taq-1A polymorphism (rs 1800497) on the preference of increasing sucrose concentrations in men with alcohol dependence. SUBJECTS AND METHODS 63 male patients with alcohol dependence were genotyped f...

Objective: Attention deficit/hyperactivity disorder (ADHD) is diagnosed using Diagnostic and Statistical Manual of Mental Disorders criteria, neuropsychological testing, examinations, and parent, teacher, and self-evaluation forms. No biological, electrophysiological, or neuroimaging markers currently exist to diagnose ADHD. Many studies about the biological markers for diagnosing ADHD have bee...

Background The influence of surgery on olfaction in patients who suffer from chronic rhinosinusitis (CRS) is still not fully understood. Most particularly, the time course of the recovery is poorly studied. Methods The prospective study describes the results of the Sniffin' Sticks identification test in 41 subjects before (V1), 2 weeks after (V2), and 6 months after (V3) endonasal sinus surge...

OBJECTIVES Olfactory meningiomas are rare benign tumours and represent about 12% of all basal meningiomas. Anosmia is thought to be among the first symptoms, even though patients often present with headaches or visual problems. However, so far no detailed psychophysical tests of olfactory function have been performed in a large number of those patients. METHODS Twelve patients (five men, seve...

The relationship between Parkinson's disease (PD) and olfactory dysfunction has been investigated via psychophysical and electrophysiological assessments. Despite the increasing number of electrophysiological studies focusing on olfactory function, there are still some limitations to observe the chemosensory event-related potentials (CSERP), which are electrophysiological responses of the brain...

Background Common sinonasal disorders include chronic rhinosinusitis (CRS), allergic rhinitis (AR), and a deviated nasal septum (DNS), which often coexist with shared common symptoms including obstruction, olfactory dysfunction, rhinorrhea. Various objective outcome measures patient-reported (PROMs) are used to assess disease severity; however, there is limited evidence in the literature on cor...

Introduction Dupilumab is the first approved antibody-based systemic add-on treatment option in Germany for severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP). The aim of this study to compare and evaluate response patients treated dupilumab 300mg every 2 weeks our clinic since 2019 based on some parameters necessary indication monitoring therapy better assess impact therapy....

Hyposmia is one of the early signs in idiopathic Parkinson's disease (PD). Olfactory stimuli were applied during fMRI scanning to show disease-related modulation of central nervous system structures and to advance our understanding of olfactory dysfunction in PD patients. All participants received either unpleasant stimuli that smelled like rotten eggs or pleasant ones that smelled like roses. ...

Problems of inadequate nutrition and energy intake are common in the aging population. Smell and taste deficits associated with Late-Onset Alzheimer’s Disease (LOAD) may accentuate the decline in nutritional status of elderly individuals and indirectly enhance progression of cognitive problems in LOAD. The objective of this study was to explore and characterize smell and taste recognition abili...