Within the past year the mode of action of biotin has become increasingly clarified. The relation of this vitamin to oxalacetic acid decarboxylation was discovered independently in at least four laboratories (l-l), while its apparent role in the synthesis of oleic acid has been suggested by Williams et al. (5) and Snell et al. (6). Biotin has further been shown to activate the deamination of as...

Department of Bioengineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom Department of Mechanical and Industrial Engineering, Northeastern University, 365 Snell Engineering Center, Boston, MA 02115, USA Department of Ophthalmology, Boston University School of Medicine, 715 Albany St., Room L914, Boston MA 02118, USA d School of Optometry, University of Waterloo, 20...

BACKGROUND Multi-state models are appropriate for cancer studies such as gastrectomy which have high mortality statistics. These models can be used to better describe the natural disease process. But reaching that goal requires making assumptions like Markov and homogeneity with time. The present study aims to investigate these hypotheses. MATERIALS AND METHODS Data from 330 patients with gas...

In 1939 Gladstone clearly demonstrated the phenomenon of amino acid antagonism and showed its relationship to the nutrition of the pathogen Bacillus anthracis. Among the interrelationships involving specific amino acids was the ability of threonine to remove the toxic effects of serine and vice versa. Snell and Guirard (1943) noted the inhibition of growth of Streptococcus lactis by glycine, se...

BACKGROUND Gastric cancer is the one of the most prevalent reason of cancer-related death in the world. Survival of patients after surgery involves identifying risk factors. There are various models to detect the effect of risk factors on patients' survival. The present study aims at evaluating these models. METHODS Data from 330 gastric cancer patients diagnosed at the Iran cancer institute ...

Combating the social and economic consequences of a growing elderly population will require the identification of interventions that slow the development of age-related diseases. Preserved cellular homeostasis and delayed aging have been previously linked to reduced cell proliferation and protein synthesis rates. To determine whether changes in these processes may contribute to or predict delay...