Excess dietary salt intake contributes to or exacerbates some forms of hypertension by increasing sympathetic nerve activity (SNA) and arterial blood pressure (ABP) through angiotensin II (Ang II) type 1 receptor activation in the rostral ventrolateral medulla (RVLM). Despite this interaction among dietary salt, Ang II, and the RVLM, no studies have directly examined whether dietary salt by its...

Social network analysis (SNA) has much to offer sociology. However, there is little consideration of SNA in contemporary sociological theory (CST) although SNA developed in parallel with the consolidation of CST in the 1960s and 1970s. SNA championed its distinctiveness as ‘structural analysis’. Nearly all current CST presents ‘structure versus agency’ as the crucial binary to differentiate mai...

Sympathetic nervous system activity is increased in several cardiovascular diseases, including hypertension and heart failure (HF).1 Indeed, one classification of the severity of HF is based on the direct relationship between the plasma concentration of the sympathetic neurotransmitter, norepinephrine, and impaired cardiac function.1 Although the role of increased sympathetic nerve activity (SN...

Sympathetic nervous system activity is increased in several cardiovascular diseases, including hypertension and heart failure (HF).1 Indeed, one classification of the severity of HF is based on the direct relationship between the plasma concentration of the sympathetic neurotransmitter, norepinephrine, and impaired cardiac function.1 Although the role of increased sympathetic nerve activity (SN...

Interindividual variability in sympathetic nerve activity (SNA) has provided insight into integrative mechanisms contributing to blood pressure (BP) regulation in humans. In young people, the influence of high SNA on BP is balanced by lower cardiac output and less adrenergic vasoconstrictor responsiveness. Older people have higher SNA and higher BP. We hypothesized that SNA has a restraining ef...

Spontaneous pain, a poorly understood aspect of human neuropathic pain, is indicated in animals by spontaneous foot lifting (SFL). To determine whether SFL is caused by spontaneous firing in nociceptive neurons, we studied the following groups of rats: (1) untreated; (2) spinal nerve axotomy (SNA), L5 SNA 1 week earlier; (3) mSNA (modified SNA), SNA plus loose ligation of the adjacent L4 spinal...

The reflex mechanisms that produce the neurocirculatory adjustments to hemorrhagic hypotension are incompletely understood. The goal of this study was to determine if hemorrhagic hypotension in rats produces differential effects on sympathetic outflow to the adrenal gland and kidney and if the two sympathetic nerve responses are governed by different reflex mechanisms. We performed simultaneous...

The effects of satavaptan (SR121463B), a novel long-acting orally active vasopressin V(2)-receptor antagonist, were investigated in patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). In the first part of this randomized, double-blind study, 34 patients first were treated with satavaptan (versus placebo) for up to 5 d and then during 23 d of open-label dosage-adj...

Although leptin is known to increase sympathetic nerve activity (SNA), we tested the hypothesis that leptin also enhances baroreflex control of SNA and heart rate (HR). Using α-chloralose anesthetized male rats, mean arterial pressure (MAP), HR, lumbar SNA (LSNA), splanchnic SNA (SSNA), and renal SNA (RSNA) were recorded before and for 2 hours after lateral cerebroventricular leptin or artifici...