Six patients, aged from 16 to 56 with various types of glomerulonephritis and deteriorating renal function underwent a total of four to six 2!-litre plasma exchanges using the Haemonectics-30 intermittent flow separator at 4-7 day intervals. The replacement fluid consisted of 2 litres of either plasma protein fraction or polygeline with 500 ml of normal saline containing 5000 units of heparin a...

Three urea cycle enzymes, argininosuccinate synthetase, argininosuccinate lyase, and argÃ1⁄4Ã-ase, and two amino acyl-RNA synthetases, the glutamyl and the glutaminyl enzymes, have been studied in the Novikoff hepatoma and Morris Hepatomas 7787, 7793, and 7800. Except for Hepatoma 7793, which had "normal" activities of the 3 urea cycle enzymes, other hepatomas had lower activities than normal l...

The starch gel electrophoretic isozyme patterns of phosphoglucomutase. glucose-6-phosphate dehydrogenase, hexokinase (HK), pyruvate kinase (PK), and lactate dehydrogenase in the cancerous and in the apparently uninvolved regions of livers from human primary hepatoma patients were compared. The HK, PK, and lactate dehydrogenase isozyme patterns in hepatoma were also compared with those in normal...

The successful duplication of genomic DNA during S phase is essential for the proper transmission of genetic information to the next generation of cells. Perturbation of normal DNA replication by extrinsic stimuli or intrinsic stress can result in stalled replication forks, ultimately leading to abnormal chromatin structures and activation of the DNA damage response. On formation of stalled rep...

At present, there are 24 genes associated with FSGS that follow Mendelian patterns of inheritance. These patterns of inheritance include autosomal recessive, autosomal dominant, and X-linked as well as inheritance of mitochondrial DNA. The phenotypes include syndromic FSGS, in which manifestations occur in other tissues, and nonsyndromic FSGS, in which disease is limited to the kidney. The list...

The epigenome is at the interface between environmental factors and genome, regulating gene transcription, DNA repair, replication. Epigenetic modifications play a crucial role in establishing maintaining cell identity are especially for neurology, musculoskeletal integrity, function of immune system. Mutations genes encoding components epigenetic machinery lead to development distinct disorder...