A full-order dynamic model of the pulse-width modulation (PWM) DC-to-DC SEPIC converter in discontinuous conduction mode (DCM) is presented in this paper. The derivation procedure is based on the smallsignal PWM switch model in DCM used in conjunction with a PWM derived SEPIC topology. The small-signal characteristics of the PWM SEPIC converter in DCM obtained in a similar way as the small-sign...

The paper describes a method for automated smallsignal frequency response analysis based on transient response obtained using a general-purpose simulation tool such as simulation program with integrated circuit emphasis (SPICE). The method is based on using the simulation tool to evaluate the converter impulse response. The main advantage of the proposed method as a design verification tool is ...

Neuroscience research spans multiple spatiotemporal scales, from subsecond dynamics of individual neurons to the slow coordination of billions of neurons during resting state and sleep. Here it is shown that a single functional principle-temporal fluctuations in oscillation peak frequency ("frequency sliding")-can be used as a common analysis approach to bridge multiple scales within neuroscien...

The primary visual cortex (V1) is widely regarded as faithfully conveying the physical properties of visual stimuli. Thus, experience-induced changes in V1 are often interpreted as improving visual perception (i.e., perceptual learning). Here we describe how, with experience, cue-evoked oscillations emerge in V1 to convey expected reward time as well as to relate experienced reward rate. We sho...

Hippocampal oscillations are dynamic, with unique oscillatory frequencies present during different behavioral states. To examine the extent to which these oscillations reflect neuron engagement in distinct local circuit processes that are important for memory, we recorded single cell and local field potential activity from the CA1 region of the hippocampus as rats performed a context-guided odo...

A central goal of neuroscience is to determine how the brain's relatively static anatomy can support dynamic cortical function, i.e., cortical function that varies according to task demands. In pursuit of this goal, scientists have produced a large number of experimental results and established influential conceptual frameworks, in particular communication-through-coherence (CTC) and gating-by-...

The phase of ongoing theta (4-8 Hz) and alpha (8-12 Hz) electrophysiological oscillations is coupled to high gamma (80-150 Hz) amplitude, which suggests that low-frequency oscillations modulate local cortical activity. While this phase-amplitude coupling (PAC) has been demonstrated in a variety of tasks and cortical regions, it has not been shown whether task demands differentially affect the r...

Electroencephalography (EEG) has been instrumental in making discoveries about cognition, brain function, and dysfunction. However, where do EEG signals come from and what do they mean? The purpose of this paper is to argue that we know shockingly little about the answer to this question, to highlight what we do know, how important the answers are, and how modern neuroscience technologies that ...

The magnitude, duration and oscillation of cellular signalling pathway responses are often limited by negative feedback loops, defined as an 'activator-induced inhibitor' regulatory motif. Within the NFκB signalling pathway, a key negative feedback regulator is IκBα. We show here that, contrary to current understanding, NFκB-inducible expression is not sufficient for providing effective negativ...

Rhythmic activity plays a central role in neural computations and brain functions ranging from homeostasis to attention, as well as in neurological and neuropsychiatric disorders. Despite this pervasiveness, little is known about the mechanisms whereby the frequency and power of oscillatory activity are modulated, and how they reflect the inputs received by neurons. Numerous studies have report...