In the treatment of respiratory allergies Sublingual Immunotherapy (SLIT) represents a valid alternative to Subcutaneous Immunotherapy (SCIT) for its better safety profile. We describe a case of acute severe asthma following the first maintenance dose of SLIT in a boy allergic to Parietaria pollen. At the initiation of therapy, the patient was in healthy condition and his asthma appeared to be ...

The amyloid precursor protein (APP) is a receptor-like membrane protein. Although APP processing and β-amyloid production play a central role in Alzheimer's disease (AD) pathogenesis, the physiological function of APP remains elusive. Here, we identify APP as a novel receptor for Slit that mediates axon guidance and neural circuit formation. APP deficiency abolishes the Slit repulsive effect in...

To the Editor, "Indian Medical Gazette." Sir,?In my report of the case of the infant with the tight foreskin producing suspended respiration and diminished action of the heart, an extraordinary peculiarity of symptom was inadvertently omitted. The day after the operation of slitting up the foreskin, the urine assumed a claret colour and Btained the bed-clothes for several days, lhis passed off ...

OBJECTIVE To describe a novel spinous process-splitting hemilaminoplasty technique for the surgical treatment of intradural and posterior epidural lesions that promotes physiological restoration. METHODS The spinous process was split, the area of the facet lamina junction was drilled, and en bloc hemilaminectomy was then performed. After removing intradural and posterior epidural lesions, we ...

Sodium, potassium, and chloride concentrations were determined in the sheath cells and axoplasm of the nerve fiber of the squid Sepioteuthis sepioidea. The sheaths were obtained by slitting the nerve fiber, the extracellular electrolytes were washed out in isotonic sucrose solution, and the concentrations in the cells were determined after different soaking times in the sucrose solution. Values...

BACKGROUND Currently accepted therapies for ragweed allergy in North America consist of pharmacotherapy and subcutaneous allergen immunotherapy injections to treat symptoms. Allergen immunotherapy not only reduces symptoms and the need for pharmacotherapy but has also been shown to have disease-modifying potential. Recently, ragweed immunotherapy administered via sublingual allergen tablet has ...

In the previous lecture we saw the algorithm that builds a decision tree based on a sample. The decision tree is build until zero training error. As we saw before, our goal is to minimize the testing error and not the training error. In order to minimize the testing error, we have two basic options. The first option is to decide to do early stopping. Namely, stop building the decision tree at s...

We investigate the two-stage guillotine two-dimensional cutting stock problem. This problem commonly arises in the industry when small rectangular items need to be cut out of large stock sheets. We propose an integer programming formulation that extends the well-known Gilmore and Gomory model by explicitly considering solutions that are obtained by both slitting some stock sheets down their wid...