نتایج جستجو برای: sledai
تعداد نتایج: 798 فیلتر نتایج به سال:
BACKGROUND The phenotypic stability of mixed connective tissue disease (MCTD) is not clear, and knowledge about disease activity and remission is scarce. We aimed to establish the occurrence of evolution from MCTD to another defined rheumatic condition, and the prevalence and durability of remission after long-term observation. METHODS In this large population-based prospective observational ...
Background Many pediatric rheumatic diseases persist into adulthood, with negative squeal from the disease or its treatment. We aimed to assess health related quality of life in a group of children with rheumatic diseases and its relation to disease activity and functional disability. Materials and Methods Fifty one patients were divided into three groups: Group 1 includes 27 patients diagnose...
Abstract Background Depression is common in systemic lupus erythematosus (SLE) and an unmeasured risk factor, yet its symptoms can be neglected standard disease evaluations. The purpose of this study was to assess the frequency impact depression on quality life SLE patients. We recruited 32 patients with 15 healthy control volunteers study. following investigations were undertaken each patient:...
OBJECTIVES To assess the serum level of matrix metalloproteinase-3 (MMP-3) in systemic lupus erythematosus (SLE) patients and correlate it with clinical manifestations, laboratory findings, disease activity and damage. METHODS Forty-two female SLE patients were included in the present study. Full history taking, thorough examination and investigations were performed. Disease activity was asse...
We present a retrospective review of DNA immunoadsorption (DNA-IA) therapy on clinical symptoms as well as indicators in pediatric cases with systemic lupus erythematosus (SLE), and follow up the shortterm curative effects. 16 SLE cases were treated by DNA-IA for 3 times every other day. We observed the changes on clinical manifestations and immunological indicators, in order to compare the alt...
OBJECTIVES To describe disease characteristics and treatment modalities in a multidisciplinary cohort of systemic lupus erythematosus (SLE) patients in Switzerland. METHODS Cross-sectional analysis of 255 patients included in the Swiss SLE Cohort and coming from centres specialised in Clinical Immunology, Internal Medicine, Nephrology and Rheumatology. Clinical data were collected with a stan...
PURPOSE To determine the association between the number of flares systemic lupus erythematosus (SLE) patients experience and damage accrual, independently of other known risk factors. METHODS SLE patients (34 centres, nine Latin American countries) with a recent diagnosis (≤2 years) and ≥3 evaluations were studied. Disease activity was ascertained with the Systemic Lupus Erythematosus Disease...
OBJECTIVE To evaluate liver and spleen dimensions in childhood-onset systemic lupus erythematosus (c-SLE) patients and healthy controls. METHODS 30 c-SLE patients and 30 healthy control volunteers underwent abdominal ultrasound. The following two liver measurements were performed in left hepatic lobe: craniocaudal and anteroposterior and three in right hepatic lobe (RHL): posterior craniocaud...
Systemic lupus erythematosus (SLE) is characterized by generalized immune activation. Part of this might be explained by a decreased rate of apoptosis, possibly related to elevated levels of soluble Fas (sFas) which can inhibit Fas mediated apoptosis of lymphocytes. In order to substantiate the relation between levels of sFas and lymphocyte activation in SLE we monitored sFas levels, lymphocyte...
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