The sodium-activated potassium channels Slick (Slo2.1, KCNT2) and Slack (Slo2.2, KCNT1) are paralogous channels of the Slo family of high-conductance potassium channels. Slick and Slack channels are widely distributed in the mammalian CNS and they play a role in slow afterhyperpolarization, generation of depolarizing afterpotentials and in setting and stabilizing the resting potential. In the p...

In banking system the evaluation of productivity and performance is key factor among fundamental concepts in management. For identify potential a bank efficiency parameter to evaluate effective system. To measure selection appropriate input-output variables one most vital issues. The suitable identification helps create model order analysis. Data Envelopment Analysis (DEA) mathematical approach...

Datacenters running on-line, data-intensive applications (OLDIs) consume significant amounts of energy. However, reducing their energy is challenging due to their tight response time requirements. A key aspect of OLDIs is that each user query goes to all or many of the nodes in the cluster, so that the overall time budget is dictated by the tail of the replies’ latency distribution. Previous wo...

Organizational slack has been recognized as critical to firm performance, although its impact is not always positive. Slack may be used to fuel innovation or alternatively excess resources may be squandered on pet projects. However, most research on slack is rooted in studying private firms in developed economies, especially the United States. Whether prior research on organizational slack can ...

Potassium channels activated by intracellular Na(+) ions (K(Na)) play several distinct roles in regulating the firing patterns of neurons, and, at the single channel level, their properties are quite diverse. Two known genes, Slick and Slack, encode K(Na) channels. We have now found that Slick and Slack subunits coassemble to form heteromeric channels that differ from the homomers in their unit...

A slack-based feasible interior point method is described which can be derived as a modification of infeasible methods. The modification is minor for most line search methods, but trust region methods require special attention. It is shown how the Cauchy point, which is often computed in trust region methods, must be modified so that the feasible method is effective for problems containing both...

Scheduling dependent tasks is one of the most challenging problems in parallel and distributed systems. It is known to be computationally intractable in its general form as well as several restricted cases. An interesting application of scheduling is in the area of energy awareness for mobile battery operated devices where minimizing the energy utilized is the most important scheduling policy c...

We consider the use of the sequential quadratic programming (SQP) technique for solving the inequality constrained minimization problem min x f(x) subject to: g i (x) 0; i = 1; : : :; m: SQP methods require the use of an auxiliary function, called a merit function or line-search function, for assessing the steps that are generated. We derive a merit function by adding slack variables to create ...

In this paper, we employ the reduced basis method for the efficient and reliable solution of parametrized optimal control problems governed by scalar coercive elliptic partial differential equations. We consider the standard linear-quadratic problem setting with distributed control and unilateral control constraints. For this problem class, we propose two different reduced basis approximations ...

This paper suggests to revisit the concept of organizational slack and its relation to performance. Three case studies are first presented, each dealing with a specific situation regarding the availability of organizational knowledge. Based on the case studies, the paper then introduces a map of organizational knowledge, discussing how firms can surf in between two polar extremes, namely lack a...