background: the tuberculin test is widely used to identify tuberculosis infection. some individuals infected with mycobacterium tuberculosis may have an initial negative skin test reaction to tuberculin. the two step purified protein derivative skin test can decrease misinterpretation of tuberculin test .this study was aimed at comparing the two- step tuberculin skin test and booster phenomenon...

Two antigens from Mycobacterium tuberculosis, ESAT-6 and MPT64, elicited delayed-type hypersensitivity (DTH) skin responses in outbred guinea pigs infected with M. tuberculosis by the aerosol and intravenous routes but not those sensitized with M. bovis BCG or M. avium. The DTH epitope of ESAT-6 was mapped to the C terminus. Nonresponders to the individual antigens were found, but all animals r...

BACKGROUND Injection drug users are at increased risk of Mycobacterium tuberculosis infection and active tuberculosis (TB). The primary objective of this study was to determine the prevalence of M. tuberculosis infection among injection drug users in Toronto, as indicated by a positive tuberculin skin test result. An additional objective was to identify predictors of a positive skin test result...

BACKGROUND & OBJECTIVES Purified protein derivative (PPD) is currently the only available skin test reagent used worldwide for the diagnosis of tuberculosis (TB). The aim of this study was to develop a Mycobacterium tuberculosis specific skin test reagent, without false positive results due to Bacillus Calmette-Guerin (BCG) vaccination using recombinant antigens. METHODS Proteins in PPD IC-65...

Tuberculosis is still a common disease, even in some parts of developing countries. Although its major impact is pulmonary, the tuberculosis is actually a disseminated disease. An unusual form of renal involvement of tuberculosis is glomerulonephritis, as a part of systemic vasculitis, Henoch-Schoenlein Purpura (HSP). A 41-year-old man, being treated with antituberculous agents for pulmonary tu...

Methods This case control study was conducted in the Respiratory Unit, Teaching Hospital Kandy Sri Lanka Around 800 new tuberculosis patients are diagnosed in this center annually. The study was carried out for a period of one year from 1 July 2010 to 30 June 2011. The patients with tuberculosis who presented to the Respiratory clinic due to anti-tuberculosis drug induced hepatitis or skin reac...

BACKGROUND Reactivation of a latent Mycobacterium tuberculosis infection in immunocompromised individuals is associated with significant morbidity and mortality. The limited sensitivity of the established tuberculin skin-test in identifying latently infected patients on immunosuppressive drug therapy represents a major obstacle to better tuberculosis control after transplantation. METHODS In ...

Airborne transmission through infectious droplet nuclei Characteristics of an infectious patient Air circulation and ventilation Reducing expulsion of infectious material from source cases Host immune response Other modes of transmission: M. bovis Evaluation of the sensitivity of the tuberculin skin test Problems with the specificity of the tuberculin skin test in veterinary medicine Standardiz...

INTRODUCTION Tuberculous pleural effusions are not always easy to diagnose but the presence of a lymphocyte-rich exudate associated with an increased adenosine deaminase level and a positive skin test result are highly sensitive diagnostic signs. CASE PRESENTATION We report a case of pleural tuberculosis in a 31-year-old white male patient from Caracas, Venezuela who was negative for human im...