Heritable skin diseases consist of a group of conditions in which the cutaneous findings can be relatively minor at one end of the spectrum, whereas at the other end the cutaneous manifestations—often part of multisystem pathology—can cause significant morbidity and untimely demise of the affected individuals (Uitto et al., 2012). Tremendous progress has been made in the past two decades in mol...

Neonatal skin may play host to a variety of dermatological conditions, ranging in spectrum from benign, self-limited disorders to severe and/or life-threatening disease. Neonatal skin disorders may be of concern to parents and physicians alike, and may initially be evaluated in the urgent care clinic or emergency department, where specialty consultation may not always be readily available. In t...

AIMS The objective of this study was to quantify the risk of serious blood and skin disorders associated with co-trimoxazole. METHODS We conducted a population-based cohort study of serious blood and skin disorders requiring hospitalization among otherwise healthy users of co-trimoxazole at Group Health Cooperative and Puget Sound (GHC). RESULTS During the years 1987 to 1993 we found six ca...

The first manifestations that appear under zinc deficiency are skin defects such as dermatitis, alopecia, acne, eczema, dry, and scaling skin. Several genetic disorders including acrodermatitis enteropathica (also known as Danbolt-Closs syndrome) and Brandt's syndrome are highly related to zinc deficiency. However, the zinc-related molecular mechanisms underlying normal skin development and hom...

For centuries skin pigmentation has played a major societal role, and genetic disorders of skin pigmentation have always evoked the curiosity of both laypersons and physicians. Normal skin pigmentation is a complex process that begins with the synthesis of melanin within the melanocytes, followed by its transfer to neighboring keratinocytes where it is translocated to the upper pole of the nucl...

Background: Endocrine disorders occasionally manifest themselves by their associated or induced cutaneous abnormalities. Skin is a frequently overlooked source of pathology. Several cutaneous abnormalities are more prevalent in diabetes mellitus. The purpose of the study was to evaluate the frequency of skin infections among type 2 diabetic patients and associated risk factors in Faisalab...