نتایج جستجو برای: sk br 3
تعداد نتایج: 1847549 فیلتر نتایج به سال:
Morin (2',3,4',5,7‑pentahydroxyflavone), a flavonoid isolated from members of the Moraceae family and leaves Cudranaia tricuspidata Buread, is well‑known natural substance with anti‑inflammatory, antioxidative, antimetastasis, anticancer effects. However, its activity has not been comprehensively investigated in human epidermal growth factor receptor 2 (HER2)‑overexpressing breast canc...
Retinoic acid receptor (RAR) a has been shown to play a role in retinoid-induced growth Inhibition of human breast cancer cell lines that express the estrogen receptor (ER). The dogma in the field has been that ER-positive breast cancer cell lines respond to retinoid treatment because they express RARa, whereas ER-negative breast cancer cell lines are refractory to retinold treatment and have b...
Lentiviral expression vectors carrying human NRP-1 short hairpin RNA (shRNA) were constructed and selected to present highly efficient NRP-1/shRNA interference sequences, in order to investigate the effects of RNA interference (RNAi)-mediated NRP-1 silencing on the biological activities of breast cancer cells. Three pairs of human NRP-1 targeted specific interference sequences and one pair of n...
انتخاب اب ار انتقام ژن در ژن در انی سرطان یک وضوع بسیار پراهمیت است. حا ل ژنقی بایقد بتوانقد و کقوم های dna را به شکل ذرات نانو تری ناسی برای اندوسیتوز تراام انقد و هقم چنقین بتوانقد رهقایش ژن از اجق ای اندوزویبهداخلسیتوزومراارتقابخشد.ازطرفی وفقیتژندرانیبهانتقاماارا?قدژنهقایدرقانیبقهسقلوم های اختصاصی سرطانی بستگی دارد. دندریمرهای پلی ا? یدوا? ین )pamam( حا ل های انتققام ژن بسقیار اارا? قدی هس...
Aromatase plays a critical role in breast cancer development by converting androgen to estrogen. In this report, results are presented to demonstrate that estrogen, the product of aromatase, can up-regulate its expression. Estrogen receptor (ER) transient transfection experiments were performed using the SK-BR-3 breast cancer cell line, which is ER negative and expresses aromatase. When SK-BR-3...
BACKGROUND AND PURPOSE The aim of this study was to determine the potency and molecular mechanism of action of YM155, a first-in-class survivin inhibitor that is currently under phase I/II clinical investigations, in various drug-resistant breast cancers including the oestrogen receptor positive (ER(+) ) tamoxifen-resistant breast cancer and the caspase-3-deficient breast cancer. EXPERIMENTAL...
BACKGROUND Propofol (2, 6-diisopropylphenol) is an intravenous sedative-hypnotic agent administered to induce and maintain anesthesia. It has been recently revealed that propofol has anticancer properties including direct and indirect suppression of the viability and proliferation of cancer cells by promoting apoptosis in some cancer cell lines. METHODOLOGY/PRINCIPAL FINDINGS This study aimed...
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