yV-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide was fed to 50 female 5-week-old Swiss mice at a dose of 0.094% by weight of diet for 46 weeks, followed by 7 weeks of the control diet. Fifty-six mice received only the control diet. Thirty-three test mice survived 40 weeks or longer and had the following tumor incidences: urinary bladder, 31/33; generalized leukemia, 23/33; lung, 6/33; and 1 uterin...

Transmembrane helices and the helical bundles which they form are the major building blocks of membrane proteins. Since helices are characterized by a given periodicity, it is possible to search for patterns of traits which typify one side of the helix and not the other (e.g. amphipathic helices contain a polar and apolar sides). Using Fourier transformation we have analyzed solved membrane pro...

QUESTIONS UNDER STUDY Despite the importance of the relationship between retirement and health only a limited amount of empirical research has addressed this issue, particularly concerning physical health. This study examines whether retirement has a short-term influence on six health measures. METHODS Using data from the Swiss Household Panel from 1999 to 2003, we perform an ordinal regressi...

The hierarchy of separation axioms that is familiar from topological spaces generalizes to spaces with an isotone and expansive closure function. Neither additivity nor idempotence of the closure function must be assumed.

This longitudinal study examines whether family processes (family cohesion and family conflict) mediate the relationship between family separation experiences and the development of peer relationships (quality and conflict). The study includes a sample of 199 early adolescent Latinos from immigrant families. Family conflict mediated the relationship between separation experiences from fathers a...

The construction and testing of a portable energy-sensitive neutron instrument are described. This instrument has been designed and constructed for the primary purpose of characterizing cosmic-ray neutron fields in the upper atmosphere and in cosmic reference field facilities. The instrument comprises a helium-3 proportional counter surrounded by 15 mm of lead and 140 mm of polyethylene creatin...

Can the foreign accent of a speaker be recognized based on suprasegmental temporal information? For a perception experiment we created stimuli based on German sentences read by six French and six English speakers. These foreignaccented sentences were manipulated by (1) applying a lowpass filter with a cutoff frequency of 300 Hz and (2) applying the same lowpass filter and monotonizing F0. In a ...

This paper shows that measures of text-to-tune alignment (i.e. analyses of f0 target points in relation to segmental landmarks) are able to shed light on significant prosodic differences in read speech between a group of six speakers of standard French from Northern France and a group of six speakers of Swiss French from the Vaud canton. The tonal targets measured in this study seemed to be anc...

We construct a composite index to measure the real activity of Swiss economy on weekly frequency. The is based novel high-frequency data set capturing economic across distinct dimensions over long time horizon. propose six-step procedure for extracting precise business cycle signals from raw data. By means real-time evaluation, we highlight importance our proposed adjustment procedure: (i) sign...