نتایج جستجو برای: single nucleotide poly morphism
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مقدمه بیماری های چند عاملی یکی از مهمترین مباحث علوم زیستی می باشند که بدلیل تداخل عوامل محیطی و ژنتیکی به سختی از هم قابل تفکیک می باشند. سندرم متابولیک یکی از این بیماری ها است که ساز و کارهای دخیل در آن پیچیده هستند و عوامل ژنتیکی و محیطی جزء عوامل مهم در بیماریزایی این سندرم می باشند، بنابراین تعیین مدل برای بررسی این نوع بیماری ها ممکن نیست. یکی از راهکار ها جهت حل این معضل؛ استفاده از رو...
the relation between single nucleotide polymorphisms (snps) and some diseases has been concerned by many researchers. also the missing snps are quite common in genetic association studies. hence, this article investigates the relation between existing snps in dnmt1 of human chromosome 19 with colorectal cancer. this article aims is to presents an imputation method for missing snps not at random...
conclusions cyp27b1-1260 polymorphism is associated with abnormal glucose metabolism in hcv infected patients. hcv infected individuals with cyp27b1-1260 genotype cc appeared to have an increased risk of developing abnormal fpg levels. results in hcv infected patients with abnormal fpg levels, the frequency of the genotype cc was significantly higher than that in patients with normal fpg levels...
background interleukin-16 (il-16) is an immunomodulatory cytokine, which plays an important role in some inflammatory and autoimmune diseases such as hepatitis b, which is a major health concern worldwide. objectives in this study, we aimed to investigate the plausible association between il-16 polymorphism and chronic hbv susceptibility in an iranian population. conclusions these findings show...
background: polycystic ovary syndrome (pcos) is one of the most common endocrine women’s disorders in reproductive age. hyperandrogenism has a critical role in the etiology of pcos and it can cause fault in steroidogenesis process. during steroidogenesis, steroidogenic acute regulatory protein (star) seems to increase the delivery of cholesterol through mitochondrial membrane. therefore, polymo...
background: sulfatase 1 ( sulf1 ) function is to remove the 6-o-sulphate group from heparan sulfate. this action changes the binding sites of extracellular growth factors. sulf1 expression has been reported to be changed in angiogenesis. we hypothesized that single nucleotide polymorphisms (snps) of sulf1 would impact clinicopathologic characteristics. objective: study of sulf1 gene polymorphis...
بیماری عروق کرونر قلب (cad) از دلائل اصلی مرگ و میر در سراسر جهان است. در بررسی های اخیر که به صورت وسیعی در سطح ژنوم انجام گرفته است snpهای متعددی بر روی کروموزوم 9p21.3 گزارش شده است که با افزایش خطر ابتلا به cad در ارتباطند. از جمله مهم ترین این snpها rs10757274 و rs2383206 می باشند. در این مطالعه ارتباط پلی مورفیسم های rs10757274 و rs2383206 با بیماری cad در 111 فرد مبتلا به cad و 100 فرد ک...
background esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (git) neoplasms, causing almost two million deaths worldwide each year. some environmental risk factors are acknowledged; however, genetic defects can significantly contribute to predisposition to git cancers. accordingly, recent works have shown that single-nucleotide polymorphisms (snps) within m...
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