BACKGROUND Silymarin derived from silybum marianum (milk thistle), a flowering member of the daisy family, may benefit liver function in people infected with the hepatitis C virus. The aims of this pilot study were to assess the efficacy and safety of silymarin on serum hepatitis C virus (HCV) RNA, serum aminotransferases (ALT, AST) levels, liver fibrosis and well-being in patients with chronic...

The antifungal activity of ethanol extract of Silybum marianum was investigated invitro against three strains of Rhizoctonia solani at different concentrations (5, 10, 15 and 20%). Bioassay of extract was conducted by poisoned food technique with three replications. The findings showed that strain of R. solani (Eggplant) was susceptible to concentrations of S. marianum more than other strains i...

Abstract The aim of this study was to investigate secondary metabolite production in Silybum marianum L. cell suspension cultures obtained from seeds treated with gamma rays (200 and 600 Gy) 0.05% colchicine. effects these treatments on callus induction, growth, viability, silymarin were studied, along the changes transcriptome DNA sequence chalcone synthase (CHS) genes. effect radiation S. dry...

Silymarin, the polyphenolic fraction from Milk Thistle (Silybum marianum) and its main component silybinin, are used almost exclusively for hepatoprotection in humans. Silymarin offers good protection in various toxic models of experimental liver diseases in laboratory animals. It effects, by antioxidative, anti-inflammatory, antifibrotic, antilipid peroxidative, membrane stabilizing and liver ...

A reactive oxygen species has been implicated in a range of human pathological diseases such as atherosclerosis and certain cancers. Flavonoids are reported to exhibit various biological activities, including antioxidative and free radical scavenging activities. Several flavonoids obtained from barley leaves, soybean and some medicinal plants, Silybum marianum, Sophorae Flos, Cinnamon, Ephedrae...

Kutkins are group of pharmacologically active compounds present in Picrorhiza kurroa Royle (Scrophulariaceae). Picrorhiza kurroa is traditionally known as kutki and has intense bitter taste. In Ayurveda Picrorhiza kurroa is a reputed remedy for the treatment of liver diseases. The chemical composition of the Picrorhiza has been studied and active constituents are group of iridoid glycosides kno...