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Experimental autoimmune encephalomyelitis (EAE) is a mouse model that reproduces cardinal signs of clinical, histopathological, and immunological features found in Multiple Sclerosis (MS). Mast cells are suggested to be involved in the main inflammatory phases occurring during EAE development, possibly by secreting several autacoids and proteases. Among the latter, the chymase mouse mast cell p...
An important characteristic of any manufacturing system is its ability to maintain an immutable performance under changing operations conditions, the disturbances and unpredictable events that can influence the performance of system’s objectives. The determination of how much to produce of each component in each time period, in a synchronized way, arises in MRPII/ERP systems . The aim of this r...
Marine dissolved organic carbon (DOC) encompasses one of the largest reservoirs of carbon on Earth. Heterotrophic bacteria are the primary biotic force regulating the fate of this material, yet the capacity of individual strains to significantly contribute to carbon cycling is unknown. Here we quantified the ability of a single Alteromonas strain [Alteromonas sp. strain Scripps Institution of O...
Although screening for large deletions or duplications of the BRCA1 gene is becoming a routine component of the molecular diagnosis of familial breast cancer, little is known about the occurrence of such rearrangements in the BRCA2 gene. Because of the high frequency of BRCA2 mutations in breast cancer families with at least one case of male breast cancer, we selected a cohort of 39 such famili...
BACKGROUND Autophosphorylation of the Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) at T286 generates partially Ca(2+)/CaM-independent "autonomous" activity, which is thought to be required for long-term potentiation (LTP), a form of synaptic plasticity thought to underlie learning and memory. A requirement for T286 autophosphorylation also for efficient Ca(2+)/CaM-stimulated CaM...
Contribution of a Low-Barrier Hydrogen Bond to Catalysis Is Not Significant in Ketosteroid Isomerase
Low-barrier hydrogen bonds (LBHBs) have been proposed to have important influences on the enormous reaction rate increases achieved by many enzymes. Δ(5)-3-ketosteroid isomerase (KSI) catalyzes the allylic isomerization of Δ(5)-3-ketosteroid to its conjugated Δ(4)-isomers at a rate that approaches the diffusion limit. Tyr14, a catalytic residue of KSI, has been hypothesized to form an LBHB with...
*Correspondence: Ashwani Pareek, Stress Physiology and Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, Room No. 401, New Delhi 110067, India e-mail: [email protected] Plant cells are often exposed to oxidative cellular environments which result in the generation of toxic reactive oxygen species (ROS). In order to detoxify the harmful ROS, plants have ev...
We estimate an empirical lower limit for the fraction of cosmic star formation that is triggered by minor mergers in the local Universe. Splitting the star-formation budget by galaxy morphology, we find that early-type galaxies (ETGs) host ∼14% of the budget, while Sb/Sc galaxies host the bulk (∼53%) of the local star formation activity. Recent work indicates that star formation in nearby ETGs ...
Recent nucleosynthesis calculations of Type II supernovae using advanced neutrino transport determine that the early neutrino winds are proton-rich. However, a fraction of the ejecta emitted at the same time is composed of neutron-rich pockets. In this paper we calculate the nucleosynthesis contribution from the neutron-rich pockets in the hot convective bubbles of a core-collapse supernova and...
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