Radiotherapy plays an important role in the treatment of most solid tumors including head and neck squamous cell carcinoma (HNSCC). Radioresistance can lead to locoregional recurrence distant metastases. Despite significant progress research radioresistance, its prediction overcoming strategies remain challenging. This review describes potential biomarkers correlated radioresistance complex sig...

OBJECTIVES/HYPOTHESIS To review the recent cell proliferation signal pathways in the etiopathogenesis of acquired middle ear cholesteatoma. DATA SOURCES PubMed (to September 2015). REVIEW METHODS Articles about cell proliferation signal pathways in the etiopathogenesis of acquired cholesteatoma and treatment advances were searched in the PubMed database, from which 73 were included in this ...

We report a straightforward strategy to comprehensively monitor signal transduction pathway dynamics in mammalian systems. Combining targeted quantitative proteomics with highly selective phosphopeptide enrichment, we monitor, with great sensitivity, phosphorylation dynamics of the PI3K-mTOR and MAPK signaling networks. Our approach consists of a single enrichment step followed by a single targ...

Ethylene plays an important role in wide-ranging aspects of plant growth and development, includingfruit ripening, leaf and flower senescence. In this study, the expression patterns of two genes involved in theethylene signal transduction pathway (RhCTR1 and RhCTR2) were investigated during the flower openingstages in two Rosa hybrida cultivars, ‘Black magic’ and ‘Maroussia’, ...

Sphingolipid metabolism was examined in guinea-pig airway smooth muscle cells stimulated by platelet-derived growth factor (PDGF) and 4β-phorbol 12- myristate 13-acetate (PMA), as mitogens and bradykinin (BK) as non-mitogen. Stimulation of the cells by PMA and PDGF for 60 min. at 37°C induced the following changes in sphingolipid metabolites: in cells prelabeled with PH] palmitate, a 1.2 f...