The studies of visual signal transduction, or phototransduction, have played a pivotal role in elucidating the most general principles of G protein signaling, particularly in regards to the concept of signal amplification, i.e., the process by which activation of a relatively small number of G protein coupled receptors is transformed into a robust downstream signaling event. In this essay, we s...

A trace lead ion (Pb 2+ ) detection platform combining surface-enhanced Raman spectroscopy (SERS) with nucleic acid cycle multiple signal amplification.

LAMP-based platform for SARS-CoV-2 RNA detection incorporating beads to remove primer-dimers, enhance fluorescent signal and stop the reaction after amplification.

According to the fundamental laws of quantum optics, vacuum noise is inevitably added signal when one tries amplify a signal. However, it has been recently shown that noiseless amplification can be realized phase-sensitive process involved. Two schemes, correlation injection scheme and two-beam amplifier scheme, are both proposed realize multi-way in symmetrical cascaded four-wave mixing proces...

Many regulatory molecules are present in low copy numbers per cell so that significant random fluctuations emerge spontaneously. Because cell viability depends on precise regulation of key events, such signal noise has been thought to impose a threat that cells must carefully eliminate. However, the precision of control is also greatly affected by the regulatory mechanisms' capacity for sensiti...

In situ imaging of miRNA in living cells could facilitate the monitoring of the dynamic expression and distribution of miRNA and research on miRNA-related cellular processes and diseases. Given the low expression levels and even down-regulation of cellular miRNA that is associated with some diseases, amplification strategies are imperative for intracellular miRNA imaging. The present paper prop...