DC-SIGN, a lectin, which presents at the surface of immature dendritic cells, constitutes nowadays a promising target for the design of new antiviral drugs. This lectin recognizes highly glycosylated proteins present at the surface of several pathogens such as HIV, Ebola virus, Candida albicans, Mycobacterium tuberculosis, etc. Understanding the binding mode of this lectin is a topic of tremend...

The dominant design theory posits that widespread innovation adoption, at least for product innovations, happens when a vendor shakeout occurs and subsequently a dominant design of the product emerges. This paper examines how the dominant design theory holds for non-product innovations: could we expect widespread adoption to occur with alternative designs? Through the widespread adoption of Ent...

OBJECTIVE Dendritic cells bind an array of antigens and DC-SIGN has been postulated to act as a receptor for mucosal pathogen transmission. Bile salt-stimulated lipase (BSSL) from human milk potently binds DC-SIGN and blocks DC-SIGN mediated trans-infection of CD4(+) T-lymphocytes with HIV-1. Objective was to study variation in DC-SIGN binding properties and the relation between DC-SIGN binding...

The paper documents a case study in the de sign and implementation of a robotic multi agent system It illustrates known design guidelines namely that the physics of the environment must be exploited that behavior is the result from the interaction dynamics between the agent and the environment and that emergent behavior can and must be utilised whenever possible But the case study also challeng...

The popularity of educational games is partly due to the exponential growth of computer games industry. However, the purpose of educational games is different from that of entertainment games. It is always a challenge for researchers and designers in the relevant discipline to design a more effective educational game. The growth of educational games is significant especially in academic researc...

STUDY DESIGN Retrospective diagnostic study. PURPOSE To define a new radiological sign, "Baltalimani sign," in severe angular kyphosis (SAK) and to report its relationship with the risk of neurological deficits and deformity severity. OVERVIEW OF LITERATURE Baltalimani sign was previously undefined in the literature. METHODS We propose Baltalimani sign as the axial orientation of the vert...

Formal property verification (also known as model checking) is a powerful methodology that can be used to find corner-case bugs, improve verification efficiency and reduce the verification cycle. However, inconclusive formal analysis results or bounded proofs have been hindering adoption of formal technology in the industry. This paper describes a formal sign-off methodology in the presence of ...

This paper reviews the popular traffic sign detection methods prevalent in recent literature. The methods are divided into three categories: color-based, shape-based, and learningbased. Color-based detection methods from eleven different works are studied and summarized in a table for easy reference. Three shape-based detection methods are presented, and a recent method based on Hough transform...

PURPOSE To describe the pattern of glaucoma-service delivery in Scotland and identify areas for improvement, taking into account Scottish General Ophthalmic Services (GOS) arrangements and the Eye Care Integration project, and to design Scottish Intercollegiate Guidelines Network (SIGN) guidelines to refine the primary and secondary interface of glaucoma care. MATERIALS AND METHODS A glaucoma...

The division of linguistic structure into a meaningless (phonological) level and a meaningful level of morphemes and words is considered a basic design feature of human language. Although established sign languages, like spoken languages, have been shown to be characterized by this bifurcation, no information has been available about the way in which such structure arises. We report here on a n...