Background: There are many parameters that modulate the severity of sickle cell anemia. Fetal hemoglobin (Hb F) is one of these major variables. However, its effect is clinically inconsistent. We conducted a descriptive study to assess the influence of Hb F on clinical events and hematological variables in patients with sickle cell anemia. Methods: 151 patients with sickle cell anemia with a st...

of renal medulla.2 Studies in pediatric patients had revealed that renal damage starts during childhood and continues throughout life. Prolonged glomerular hyperfiltration in SCD during childhood and early adult years leads to glomerular injury, resulting in glomerular sclerosis, proteinuria, and progressive renal failure.3 Microalbuminuria is an early manifestation of sickle cell-related renal...

Objective:  The aim of this study was to assess clinical laboratory funding for differential diagnosis of sickle cell disease (SCD) and other associated disorders for better understanding of clinical types and prevention of sickling events. Material and Methods:  This is a descriptive crossed-sectional study that analyzed the peripheral blood film, sickle cell preparation, hemoglobin electroph...

background: sickle-cell disease (scd) is an inherited hemoglobin childhood disorder, frequently complicated by pulmonary hypertension and cardiac involvement. cardiovascular events and complications are the leading cause of mortality and morbidity in patients with scd. tissue doppler imaging and the myocardial performance index (tei index), are simple indices for the assessment of the cardiac f...

background & aim:combretaceae family is   known for efficacy in the management of sickle cell disorder (scd). based on   the earlier reports of anti-sickling property of terminalia genus the study investigates in vitro antisickling properties of terminalia arjuna and terminalia   bellirica. experimental: anti-sickling   assay of methanolic and aqueous extract of t. arjuna and t. bellirica   on ...

Coronavirus Disease 2019 (COVID-19) is a significant medical and public health problem in the world. It is believed that it can worsen in extreme conditions. Also, it is suggested that blood disorders such as sickle cell disease (SCD) may increase the risk of COVID-19 symptoms. The present study reports a family facing COVID-19, in which one of two members with SCD presented with fever, repeate...

background: there are many parameters that modulate the severity of sickle cell anemia. fetal hemoglobin (hb f) is one of these major variables. however, its effect is clinically inconsistent. we conducted a descriptive study to assess the influence of hb f on clinical events and hematological variables in patients with sickle cell anemia. methods: 151 patients with sickle cell anemia with a st...

background: the aim of the present study was application of haemoglobin absorption spectroscopy as a distinguishing tool for identification of two haemoglobin types-hba and hbs. material and methods: millimolar absorptivities of normal adult haemoglobin (hba) and sickle cell haemoglobin (hbs) were monitored at ph values of 7.2 and 5.0, within the ultra violet and visible spectral range (250-650...