Previous studies have shown that the sickle environment is highly enriched for reactive oxygen species (ROS). We examined the oxidative effects of sickle cell disease on hematopoietic stem cell function in a sickle mouse model. In vitro colony-forming assays showed a significant decrease in progenitor colony formation derived from sickle compared to control bone marrow (BM). Sickle BM possessed...

RISKING REPRODUCTION:REPRODUCTIVE HEALTH AMONG WOMEN WITH SICKLE CELL DISEASEbyPAULA THOMPSON ROSSAugust 2013Advisor: Dr. Heather DillawayMajor: SociologyDegree: Doctor of PhilosophyReproductive health among women with sickle cell disease remains a critical gap in theliteratures on sickle cell disease, reproductive health, and women’s health. Sickle cell ...

CONTEXT Vascular occlusion in sickle cell disease causes increased levels of plasma cell-free DNA as a result of cell death and tissue damage. OBJECTIVES This study investigates plasma cell-free DNA concentrations in sickle cell disease patients, and aims at exploring the significance of plasma cell-free DNA as a potential biomarker in predicting its complications. DESIGN Plasma cell-free D...

The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57 with sickle cell anemia) at steady state. Hemoglobin oxygen saturation was measured before and immediately after the six-minute walk test. Blo...

Our objective was to document the prevalence of sickle cell anemia among scheduled tribe (Garasia) of Sirohi district in Rajasthan state and study the clinical and hematological profile of the patients with sickle cell disease (Hb SS). In this prospective cross-sectional study, 1676 Garasia tribals attending the hospital or the mobile clinic were screened for sickle cell anemia by sickling test...

BACKGROUND AND PURPOSE Large vessels are also affected in sickle cell disease. The aim of this study was to assess several parameters in adult patients with sickle cell disease compared with control subjects and in patients with sickle cell disease with stroke. METHODS Carotid arterial stiffness, intima-media thickness, and transcranial Doppler ultrasonography were measured. RESULTS Arteria...

By E. SILvEsTR0NI, M.D. AND I. BIANCO, M.D. S ICKLE CELL ANEMIA is a severe chromsic disease usually confined to the Negro race l ttt occasiotsally foutsd its imidividuals of the white race mostly of Southerti Italians on Greek stock. Clitsically there is chromsic hemolytic amsemia s ’iths crises, osteo-muscular pains, bouts of severe abcbomitsal pain and ulceratiomis of the legs. Hematological...

Sickle cell anemia was first described by Herrick in 1910. Pioneering studies by Pauling et al. established that Sickle Cell Disease (SCD) results from a defect in the hemoglobin molecule. 1 The sickle mutation was characterized several years later by Ingram et al. as a glutamine-to valine substitution at the sixth residue of the beta globin polypeptide. Homozygosity for the sickle mutation (i....

We present the anisotropic light scattering of individual red blood cells (RBCs) from a patient with sickle cell disease (SCD). To measure light scattering spectra along two independent axes of elongated-shaped sickle RBCs with arbitrary orientation, we introduce the anisotropic Fourier transform light scattering (aFTLS) technique and measured both the static and dynamic anisotropic light scatt...