Three patients with the sicca syndrome and chronic sensory neuropathy are described; in two of them neuropathy was the presenting feature of the disease. The sicca syndrome can give rise to a characteristic neurological syndrome comprising areflexia and asymmetrical sensory loss, particularly of proprioception, in the limbs. This is often associated with tonic pupils and trigeminal anaesthesia.

Our patient had been receiving the drug for ~ 3 yr and her sicca symptoms became rather profound over recent months, associated with severe swelling of the parotids. It is difficult to be certain about how long she had had positive serology for the Ro antibody in her blood as it was tested soon after the development of the sicca symptoms. Although anti-Ro is commonly associated with various con...

OBJECTIVE To examine health-related quality of life (HRQoL) and depression among participants in an international Sjögren's syndrome (SS) registry, comparing those with and without SS. METHODS Cross-sectional study of participants in the Sjögren's International Collaborative Clinical Alliance (SICCA) registry. The 2016 American College of Rheumatology/European League Against Rheumatism SS cla...

Abstract A 66-year-old woman showing renal dysfunction with elevated serum alkaline phosphatase and anti-SS-A antibody was admitted. A labial salivary gland biopsy showing infiltration of mononuclear cells and positive anti-SS-A antibody with sicca symptoms led to a diagnosis of primary Sjögren’s syndrome (SS). Fanconi’s syndrome was diagnosed by renal tubular acidosis along with renal glucosur...

A 56-year-old Japanese female simultaneously developed thrombocytopenia, sicca symptoms, and an elevation of transaminase. Antiphospholipid antibodies were detected in her serum. The presence of anti-SS-A antibodies in the serum and sialectasis, disclosed by sialography, suggested the presence of primary Sjogren's syndrome (SjS). The laboratory data and the biopsy of the liver showed compatible...

Background ACR/EULAR 2016 classification criteria for Sjögren disease (SS) 1 use 5 standard questions on ocular and oral sicca symptoms as an entrance criteria. However, these do not differentiate between SS non-SS etiology. Recently, a new 5-item Sjögren’s Syndrome Screening Questionnaire based SICCA study data was designed the in clinical practice, better differentiating from patienents. 2 Ob...