Supposedly herbal weight loss pills are sold online and are widely used in the world. Some of these products are found to contain sibutramine by FDA and their sale is prohibited. We report a case of a female patient who presented to the emergency department after taking slimming pills. 17-year-old female patient presented to the emergency room with palpitations, dizziness, anxiety, and insomnia...

Because monoamine reuptake inhibitors and releasing agents both increase extracellular neurotransmitter levels, establishing in vivo experimental criteria for their classification has been difficult. Using microdialysis in the hypothalamus of unanesthetized rats, we provide evidence that serotonin- (5-HT) selective and nonselective reuptake inhibitors can be distinguished from the 5-HT-releasin...

We used functional magnetic resonance imaging to explore brain responses to food images in overweight humans, examining independently the impact of a prescan meal ("satiety") and the anti-obesity drug sibutramine, a serotonin and noradrenaline reuptake inhibitor. We identified significantly different responses to these manipulations in amygdala, hypothalamus, and ventral striatum. Each region w...

© 2016 National Agricultural and Food Centre (Slovakia) 1 Obesity is a complexed condition, with serious social and psychological dimensions, that affects virtually all age and socioeconomic groups and threatens to overwhelm both developed and develop ing countries. In 1995, there were an estimated 200 million of obese adults worldwide and another 18 million under-five children classified as ov...

Health concerns associated with the consumption of food supplements rise in parallel popularity and market availability these products. In pursuit data related to unauthorized presence pharmaceuticals supplements, Rapid Alert System for Food Feed (RASFF) database was searched 2011–2022 period. The most “popular” adulteration were phosphodiesterase-5 inhibitors (235 records); anorexics laxatives...

OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. DESIGN Updated meta-analysis of randomised trials. DATA SOURCES Medline, Embase, the Cochrane controlled trials register, the Current Science meta-register of controlled trials, and reference lists of identified articles. All data sources were searched from December 2002 (end ...

objective: in recent years the use of herbal slimming supplements has increased in iran. one problem may be the illegal inclusion of synthetic drugs by some manufacturers in these products. the aim of this study is to determine four undeclared synthetic adulterants in some herbal slimming products present in the iranian market. methods: this survey studyresearched six common herbal slimming sup...

RESEARCH DESIGN AND METHODSdThis analysis included 8,192 overweight patients with type 2 diabetes mellitus from the Sibutramine Cardiovascular Outcomes Trial (SCOUT) randomized to lifestyle intervention with or without sibutramine for up to 6 years. Patients were grouped according to hypoglycemic treatment at baseline. The primary end point was the time from randomization to the first occurrenc...